| 郭安梅 张素芹 肖春红 郭素香 张万江.术后认知功能障碍不同诊断标准的合理性探讨[J].现代生物医学进展英文版,2014,14(23):4550-4552. |
| 术后认知功能障碍不同诊断标准的合理性探讨 |
| Research on the Rationality of Diagnosis Criterions of Postoperative Cognitive Dysfunction |
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| DOI： |
| 中文关键词: 认知障碍 神经心理学测验 诊断 标准 学习效应 |
| 英文关键词: Cognitive dysfunction Neuropsychological tests Diagnosis Criterion Learning effects |
| 基金项目:石河子大学医学院院级科研项目（YL2011S029） |
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| 中文摘要: |
| 目的：探讨目前国内外常用的三种术后认知功能障碍（Postoperative Cognitive Dysfunction, POCD）诊断标准的合理性。方
法：以100 名中青年健康志愿者为研究对象，采用神经心理学测验测定认知功能三次，第一次测定(T0)作为基础值，第二次测定1
(T1)和第三次测定(T2)分别与第一次测定间隔3d 和30d。分别按照自身对比法、标准差法和Z计分法检测健康人群中T1和T2时
认知功能变化程度超出正常范围的人数。以检测结果服从正态分布为判断标准。结果：完成全程测量者80 人。按照三种POCD
诊断标准诊断，在T1时，认知功能提高人数分别是认知功能降低人数的30 倍、17 倍和1倍，在T2时分别是32 倍、26 倍和1.5倍。
结论：在采用神经心理学方法研究POCD时，用Z计分法诊断POCD 比自身对比法和标准差法更能准确地反映认知功能的客观
变化。 |
| 英文摘要: |
| Objective:To investigate the rationality of three diagnosis criterions on postoperative cognitive dysfunction (POCD)
used in clinical study of POCD.Methods:After Research Ethics Board approval and informed consent, 100 young and middle-age
healthy volunteers were recruited. We then measured and analyzed their cognitive function change with a battery of six
neuropsychological tests on three occasions: first time (T0, baseline) and 3 day (T1), 30 day (T2) after the first time. The cases of cognitive
improvement and cognitive dysfunction on T1 and T2 with three ways, self comparison, standard deviation and Z score were detected to
assess the rationality of those. The criterion of rationality is that the detecting results follow the normal distribution.Results:80 objects
had finished all the tests. The ratio of cognitive improvement and cognitive dysfunction according to the three ways were 30, 17, 1 at T1
and 32, 26, 1.5 at T2, respectively.Conclusion:Z score may be more accurate to reflect the objective change of cognitive function than
self comparison and standard deviation when neuropsychological tests are administered in clinical study of POCD. |
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