| 谢敏妍 刘海俊 陈锦华 梁智敏 张东升 雷萍.透析充分性、微炎症、营养状态对血液透析患者生存质量及长期生存率的影响[J].现代生物医学进展英文版,2014,14(23):4532-4536. |
| 透析充分性、微炎症、营养状态对血液透析患者生存质量及长期生存率的影响 |
| The Effect of Dialysis Adequacy, Microinflammation and Nutritional Statuson the Quality of Life and Survival Rate in Maintenance Hemodialysis Patients |
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| DOI： |
| 中文关键词: 肾透析 透析充分性 微炎症 营养状况 生存质量 生存率 |
| 英文关键词: Renal dialysis Dialysis adequacy Microinflammation Nutritional status Quality of life Survival rate |
| 基金项目:广东省科技计划项目基金项目（00693731120201014） |
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| 中文摘要: |
| 目的：探讨透析充分性、微炎症、营养状态对血液透析患者生存质量及长期生存率的影响。方法：随机选择我院血液透析中
心维持透析每周3 次，治疗6 月以上的患者89 例，观察并评估其入组时、入组后第3、6、12、18、24 月的生存质量（KDTA、SF-36）、
营养状况（MQSGA、MAMC）、微炎症（hCRP、IL-6）及透析充分性（iPTH、Kt/V、beta2-MG），并分析透析充分性、营养状况、微炎症与生
存质量、生存率的相关性。结果：89 例患者有9 例死亡，死亡率为10.1 %；iPHT、MQSGA与KDTA、SF-36 呈负相关(P<0.05)，Kt/V
与KDTA、SF-36 呈正相关(P<0.05)，beta2-MG、胆固醇与KDTA、SF-36 无明显相关(P>0.05)；hCRP、IL-6 分别与KDTA、SF-36 呈负相
关(P<0.05)；HGS 与KDTA 呈正相关(P<0.05)，与SF-36 无明显相关(P>0.05)，ALB、MAMC 与KDTA、SF-36 呈正相关(P<0.05)；
Kt/V、MQSGA、IL-6、iPTH 均与KDAT 及SF-36 存回归关系(P<0.05)；Cox 回归模型发现Kt/V、ALB 及开始透析年龄是导致血透
患者死亡的危险因素(P<0.05)。结论：透析充分性、微炎症及营养状况均影响透析患者的生存质量及长期生存率；iPTH 、Kt/V、
MQSGA、IL-6 是其生存质量的独立影响因素，Kt/V、ALB 及开始透析年龄是血透患者的死亡独立危险因素。 |
| 英文摘要: |
| Objective:To study the effect of dialysis adequacy, microinflammation and nutritional status on the quality of life
(Qol) and survival rate in maintenance hemodialysis patients.Methods:This was a prospective study on 89 cases of long-term
hemodialysis patients. The Qol(KDTA, SF-36), survival rate, nutritional status(MQSGA, MAMC), microinflammation (hCRP, IL-6) and
dialysis adequacy (iPTH, Kt/V,beta2-MG) were evaluated at beginning, the 3th, 6th , 12th, 18th and 24th month, and then calculated the
means and analyzed the correlation of dialysis adequacy, microinflammation and nutritional status with Qol and survival rate.Results:9
cases out of 89 died, mortality was 10.1 %; There was negative correlation between iPTH and KDTA, SF-36, while the correlation of
Kt/V with KDTA and SF-36 was positive; There was no correlation of beta2-MG with KDTA and SF-36; there were negative correlation of
hCRP and IL-6 with KDTA and SF-36; There were negative correlation of MQSGA with KDTA and SF-36, and HGS had positive
correlation with KDTA respectively, while no correltion with SF-36; ALB and MAMC had positive correlation with KDTA and SF-36,
while there was no correlation of cholesterol with KDTA and SF-36; Kt/V, MQSGA, IL-6, iPTH had regressive association to KDTA and
SF-36; The Cox regression analysis revealed that Kt/V, ALB and beginning dialysis age were significant determinants of mortality in
long-term hemodialysis patients.Conclusion:The dialysis adequacy, microinflammation and nutritional status had effect on KDTA and
SF-36; Kt/V, MQSGA, IL-6, iPTH were the independent factors of KDTA and SF-36; Kt/V, ALB and beginning dialysis age were the
death risk factors of hemodialysis patients. |
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