| 李志杰 张卓然 韩世愈 史文华 林楠.趋化因子受体CCR3 在上皮性卵巢癌中的表达及临床意义[J].现代生物医学进展英文版,2014,14(23):4494-4496. |
| 趋化因子受体CCR3 在上皮性卵巢癌中的表达及临床意义 |
| Expression and Clinical Significance of CCR3 in Human Epithelial Ovarian Cancer |
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| DOI： |
| 中文关键词: 卵巢癌 趋化因子受体 CCR3 逆转录聚合酶反应 |
| 英文关键词: Ovarian cancer Chemokine receptor CCR3 Reverse transcriptase polymerase chain reaction |
| 基金项目:黑龙江省卫生厅科研项目（2010132） |
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| 中文摘要: |
| 目的：探讨趋化因子受体CCR3 在上皮性卵巢癌组织中的表达情况，以及其与卵巢癌临床病理特征的关系。方法：收集上皮
性卵巢癌组织、良性上皮性卵巢肿瘤组织以及正常卵巢组织标本各30 例，采用多聚腺苷酸加尾实时荧光定量反转录聚合酶链反
应[poly(A)-RT-qPCR]检测其CCR3 的表达，并分析上皮性卵巢癌组织中CCR3 的表达与患者临床病理特征之间的关系。结果：上
皮性卵巢癌组织中CCR3 的表达显著高于良性卵巢肿瘤组和正常卵巢组，差异有统计学意义(P<0.05)；且上皮性卵巢癌组织中
CCR3的表达与患者的分期、组织分级及淋巴结转移均显著相关(P<0.05)。结论：CCR3 在上皮性卵巢癌组织中呈高表达，且在上
皮性卵巢癌的发生和发展过程中均起着十分重要的作用。 |
| 英文摘要: |
| Objective:To investigate the expression of chemokine receptor CCR3 in epithelial ovarian carcinoma, and the
relationship with the clinicopathological characteristics.Methods:Tissue samples of epithelial ovarian cancer (30 cases), benign ovarian
tumor(30 cases) and normal ovarian(30 cases) were collected, the polyadenylation real-time fluorescent quantitative reverse transcription
polymerase chain reaction (A [poly) -RT-qPCR] were used to detect the expression of CCR3, and analyze the correlation of CCR3
expression with the clinicopathological characteristics.Results:The expression of CCR3 in ovarian cancer group was significantly higher
than those in the benign ovarian tumors and normal ovarian group (P<0.05), which was also markedly correlated with the staging,
histological grade and lymph node metastasis of epithelial ovarian carcinoma (P<0.05).Conclusion:The upregulation of CCR3
expression played an important role in the development of epithelial ovarian carcinoma. |
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