| 周大伟 杨兰 师小娟 李静 周琳 郭晓东.丁苯酞氯化钠注射液联合神经节苷脂治疗急性脑梗死的临床效果观察[J].现代生物医学进展英文版,2014,14(23):4482-4484. |
| 丁苯酞氯化钠注射液联合神经节苷脂治疗急性脑梗死的临床效果观察 |
| Observation on the Clinical Effects of the Butylphthalide and Sodium Chloride Injection Combinedwith the Ganglioside on the Treatment of the Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 急性脑梗死 丁苯酞 神经节苷酯 治疗效果 |
| 英文关键词: Acute cerebral infarction Butylphthalide and sodiumchloride injection Glucoside Clinical efficacy |
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| 中文摘要: |
| 目的：探讨丁苯酞和神经节苷酯治疗急性脑梗死的临床效果，为临床治疗提供可借鉴的方法。方法：选取2011 年8 月-2013
年5 月在我院接受治疗的94 例急性脑梗死患者，随机分为治疗组和对照组，每组47 例。对照组患者采取抗血小板制剂及活血药
物进行常规治疗，治疗组患者在此基础上给予丁苯酞氯化钠注射液联合单唾液酸神经节甘酯进行治疗。采用NlHSS 评定各组患
者神经功能缺损程度，应用改良Rankin 量表评定残障水平，并对两组患者的治疗效果进行对比分析。结果：两组患者治疗前的
NIHSS 与mRs 评分无明显差异(P>0.05)。两组患者治疗后的NIHSS 及mRs 评分较治疗前均获得改善，治疗组患者改善更为明
显，治疗效果明显优于对照组，差异具有统计学意义(P<0.05)。对照组患者治疗的总有效率为93.61%；治疗组患者治疗的总有效率
为97.87%。治疗组的治疗总有效率明显高于对照组，差异具有统计学意义(P<0.05)。结论：丁苯酞联合神经节苷酯治疗急性脑梗死
具有明显的治疗效果，患者治疗后的NIHSS及mRs评分得到改善，值得临床推广采用。 |
| 英文摘要: |
| Objective:To observe the clinical efficacy of the butylphthalide and sodium chloride injection combined with the
glucoside on patients with acute cerebral infarction in order to provide a reference to the clinical treatment.Methods:94 patients with the
acute cerebral infarction who were treated in our hospital between August 2011 and May 2013 were selected and randomly divided into
the treatment group and the control group, with 47 cases in each one. The patients in the control group were treated by the conventional
methods, while the patients in the treatment group were treated by the butylphthalide and sodium chloride injection combined with the
glucoside besides that of the conventional one. Then the NlHSS was used to evaluate the degree of the nerve function defection, and the
modified Rankin scale was used to evaluate the level of disability. The clinical efficacy of patients in the two groups were analyzed and
compared.Results:There was no statistically significant difference about the scores of the mRs and the NIHSS between the two groups
before treatment (P>0.05). After treatment, the NIHSS and mRs scores of the patients in the two groups were improved than before,
especially for the patients in the treatment group with statistically significant differences (P<0.05). The total clinical efficacy of the
treatment group was higher than that of the patients in the control group(P<0.05).Conclusion:It is suggested that the clinical efficacy of
the butylphthalide and sodium chloride injection combined with the glucoside on the treatment of the acute cerebral infarction could be
worthy of clinical promotion with obvious clinical efficacy. |
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