| 向勇 朱建萍 尤志珺 刘丹荣 张林.两种剂量阿托伐他汀治疗老年急性冠脉综合征的疗效及影响炎症、凝血因子的研究[J].现代生物医学进展英文版,2014,14(22):4356-4358. |
| 两种剂量阿托伐他汀治疗老年急性冠脉综合征的疗效及影响炎症、凝血因子的研究 |
| Study on the Effect and Influence on Inflammation, Coagulation Factor oftwo Doses of Atorvastatin in the Treatment of Elderly Patients with AcuteCoronary Syndrome |
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| DOI： |
| 中文关键词: 急性冠脉综合征 老年患者 阿托伐他汀 炎症因子 凝血因子 |
| 英文关键词: Acute coronary syndrome Elderly patients Atorvastatin Inflammatory factor Coagulation factor |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨两种剂量阿托伐他汀治疗老年急性冠脉综合征的疗效及对炎症、凝血因子的影响。方法：选择我院2010 年1
月～2012年12月收治的120 例老年急性冠脉综合征患者作为观察对象，根据住院号随机分为观察组和对照组，每组均60 例，两
组患者均采用阿托伐他汀治疗，对照组予以10 mg/d，观察组予以20 mg/d，比较两组的临床效果以及炎症因子、凝血因子的变化。
结果：治疗后，两组血脂达标率均显著提高，观察组治疗后1 个月的血脂达标率为33.3%，治疗后3 个月的血脂达标率为46.7%，
均显著高于对照组的15.0%、23.3%，差异均具有统计学意义（均P<0.05）；治疗后1 个月和3 个月所有患者血浆CRP 和TF 均显
著下降，观察组治疗后1 个月和3 个月CRP和TF水平均显著低于对照组，差异均具有显著性（均P<0.05）；观察组治疗后3 个月
TFPI水平显著高于对照组，差异具有统计学意义（P<0.05）。结论：大剂量阿托伐他汀治疗老年急性冠脉综合征患者临床疗效优于
小剂量，对炎症因子和凝血因子的影响有利于预后的改善，值得临床进一步推广应用。 |
| 英文摘要: |
| Objective:To investigate the effect and influence on inflammation, coagulation factor of two doses of atorvastatin in
the treatment of elderly patients with acute coronary syndrome.Methods:120 elderly patients with acute coronary syndrome in our
hospital fromJanuary 2010 to December 2012 were chosen as observation object, according to the number of hospitalized, the cases were
randomly divided into observation group and control group, each group of 60 cases, two groups of patients were treated with atorvastatin
treatment, control group was given 10 mg/d, while observation group 20 mg/d, compared the clinical effect and the changes of
inflammatory factors, coagulation factor in two groups.Results:After treatment, two groups of lipid standard rate increased significantly,
the compliance rate in observation group after 1 months treatment was 33.3%, after 3 months was 46.7%, significantly higher than that of
15.0%, 23.3% in control group, the differences were statistically significant (P<0.05); after 1 and 3 months treatment for all patients
plasma CRP and TF were significantly decreased, CRP and TF levels in observation group after 1 months and 3 months' treatment were
significantly lower than those in control group, the differences were significant (P<0.05); TFPI level in observation group after 3 months
treatment, was significantly higher than control group, the difference had statistical significance (P<0.05).Conclusion:The clinical curative
effect of high dose atorvastatin in the treatment of elderly patients with acute coronary syndrome is better than the small dose atorvastatin,
the effects on the inflammatory factors and coagulation factors can improve the prognosis, and it isworthy of further clinical application. |
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