| 闫海清 岳学静 李晶 李燕 常利.普伐他汀联合阿司匹林治疗老年缺血性脑卒中的疗效及对血脂和认知功能的影响[J].现代生物医学进展英文版,2014,14(22):4339-4342. |
| 普伐他汀联合阿司匹林治疗老年缺血性脑卒中的疗效及对血脂和认知功能的影响 |
| Effect of Pravastatin Combined with Aspirin in Treatment of ElderlyIschemic Stroke and its Affect on Blood Lipid and Cognitive Functions |
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| DOI： |
| 中文关键词: 普伐他汀 阿司匹林 缺血性脑卒中 血脂 认知功能 |
| 英文关键词: Pravastatin Aspirin Ischemic stroke Lipids Cognitive function |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨普伐他汀联合阿司匹林对老年缺血性脑卒中的治疗疗效及其对患者血脂和认知功能的影响。方法：选择我院80
例老年缺血性脑卒中患者，按入院顺序采用随机数字表法平均分为两组各40 例，两组患者均给予常规缺血性脑卒中对症治疗，
研究组患者在此基础上使用普伐他汀联合阿司匹林治疗，对照组患者仅使用阿司匹林治疗。比较两组患者治疗疗效，同时比较两
组患者血清中血脂水平及认知功能改变情况。结果：研究组患者总治疗有效率为92.5%，明显高于对照组65%，比较差异具有统计
学意义（P＜0.05）；研究组患者治疗后血脂水平较治疗前明显下降，且下降程度显著高于对照组，比较差异具有统计学意义（P＜
0.05）；研究组患者治疗后认知功能评分总分为（93.75± 11.45）分，明显高于对照组（84.11± 12.04）分，比较差异具有统计学意义
（P＜0.05）。结论：普伐他汀联合阿司匹林对老年缺血性脑卒中的治疗疗效显著，可有效改善患者血脂水平和认知功能，值得推广
应用。 |
| 英文摘要: |
| Objective:To investigate the effect of pravastatin combined with aspirin in treatment of elderly ischemic stroke and its
affect on blood lipid and cognitive functions.Methods:80 cases of elderly patients with ischemic stroke in our hospital were randomly
divided into two groups of 40 cases according to the order of admission. All patients were treated with conventional symptomatic
treatment of ischemic stroke, the study group used pravastatin combined with aspirin in addtion, while the control group used aspirin
only. The efficacy, serum lipid levels and cognitive function changes were compared between the two groups.Results:The study group's
total effective rate was 92.5%significantly higher than the control group's 65%, the difference was statistically significant (P<0.05); The
study group's lipid level was significantly decreased after treatment, and the degree of decrease was significant higher than the control
group, the difference was statistically significant (P<0.05); The study group patients' total cognitive function score was (93.75± 11.45),
significantly higher than the control group's (84.11± 12.04), the difference was statistically significant (P<0.05).Conclusion:Pravastatin
combined with aspirin has a significant effect on treatment of ischemic stroke, which can effectively improve lipid levels and cognitive
function in patients that should be widely applied. |
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