| 高娟 杨雪琴 刘顺达 张华 曲传勇 高永英 齐明山.多巴胺能药物对早期帕金森病患者睡眠障碍发生的影响[J].现代生物医学进展英文版,2014,14(22):4308-4311. |
| 多巴胺能药物对早期帕金森病患者睡眠障碍发生的影响 |
| Effects of Dopaminergic Agents on the Sleep Disorders of Parkinson DiseasePatients at Early Stage |
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| DOI： |
| 中文关键词: 帕金森病 睡眠障碍 多巴胺能药物 抑郁 |
| 英文关键词: Parkinson disease Sleep disorders Dopaminergic agents Depression |
| 基金项目:宁夏回族自治区重点科研计划课题（2012079） |
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| 中文摘要: |
| 目的：探讨多巴胺能药物及其它因素与早期帕金森病患者睡眠障碍之间的关系。方法：选择84 名早期帕金森病患者作为病
例组，87 名健康人作为对照组。采用帕金森病睡眠量表（PDSS）评价患者的睡眠状况。采用非条件Logistic 回归分析早期帕金森病
患者睡眠障碍的影响因素。结果：早期帕金森病组PDSS 总评分显著低于对照组（P = 0.000）；HAMD 评分则显著高于对照组（P =
0.000）。早期帕金森病患者睡眠障碍的主要类型为失眠。使用多巴胺能药物（OR=5.50，95%CI：1.96-15.81）是早期帕金森病患者发
生睡眠障碍的危险因素；而较低的HAMD 评分（OR=0.35，95%CI：0.13-0.93）则显著降低其睡眠障碍风险。结论：早期帕金森病患
者存在睡眠障碍，多巴胺能药物和抑郁可能促进和加重其睡眠障碍。 |
| 英文摘要: |
| Objective:To evaluate the relationship between dopaminergic agents and sleep disorders of Parkinson disease (PD)
patients at early stage.Methods:Eighty-four consecutive PD patients at early stage (Hoehn-Yahr gradeⅠ -Ⅱ ) and age-matched 87
healthy controls were enrolled in this study. Parkinson disease sleep scale (PDSS) was used to evaluate sleep status. Non-conditional
Logistic regression models were used to calculate odds ratios and its corresponding 95%confidence interval (95%CI).Results:The PDSS
score of PD group was significantly lower than that of control group (P=0.000), but the score of Hamilton depression rating scale
(HAMD) of PD group was significantly higher than that of control group (P=0.000). Agrypnia was found the main type of sleep disorder
for PD patients at early stage. Dopaminergic agents (OR=5.50, 95%CI: 1.96-15.81) could increase risk of sleep disturbance, and lower
score of HAMD (OR=0.35, 95%CI: 0.13-0.93) could decrease risk of sleep disorders among PD patients.Conclusion:Different types of
sleep disorder could be found in PD patients at early stage. Dopaminergic agents and depression may make the situation of sleep disorders
worse for PD patients at early stage. Intervention and treatment measures should be introduced to prevent development of sleep disorders
among PD patients at early stage. |
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