| 林丹 罗新 赵丽琴 蒋惠萍 易跃雄.液基细胞学和DNA倍体检测筛查宫颈病变的临床研究[J].现代生物医学进展英文版,2014,14(22):4273-4276. |
| 液基细胞学和DNA倍体检测筛查宫颈病变的临床研究 |
| The Study of Liquid-based Cytology and DNA Ploidy Screening to DetectCervical Lesions |
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| DOI： |
| 中文关键词: 液基细胞学 DNA倍体检测 宫颈病变 筛查 |
| 英文关键词: Liquid-based cytology DNA ploidy detection Cervical lesions Screening |
| 基金项目: |
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| 中文摘要: |
| 目的：研究液基细胞学和DNA倍体检测筛查宫颈病变的价值，为临床应用提供理论依据。方法：选择2011 年6 月-2013 年
5 月在我院门诊就诊或体检中心体检，行宫颈癌筛查的2034 名受试者，同时行宫颈液基细胞学检查和细胞DNA倍体分析，其中
71 人有组织病理学结果。结果：71 例组织病理学结果中，组织学诊断慢性宫颈炎33 例，CINⅠ21 例，CINⅡ11 例，CINⅢ6 例；液基
细胞学TBS 分级26 例WNL，24 例ASCUS，4 例ASC-H，14 例LSIL，3 例HSIL；DNA 定量细胞学异倍体细胞数0 个24 例，1~2
个35 例，3~14 个11 例，15~个1 例。ROC曲线液基细胞学曲线下面积为0.921（95%CI为0.859~0.983），DNA 倍体检测曲线下面
积为0.836（95%CI为0.743~0.929）。结论：液基细胞学与DNA倍体检测对筛查宫颈病变有较高的预测价值，值得在临床上推广应
用。 |
| 英文摘要: |
| Objective:To study the value of liquid-based cytology and DNA ploidy screening on detecting cervical lesions, so as
to provide a theoretical basis for clinical applications.Methods:2034 cervical cancer screening subjects were selected in our hospital
from June 2011 to May 2013. All of them received liquid-based cervical cytology and cell DNA ploidy analysis, and 71 cases turned out
with histopathology results.Results:Among the 71 cases with histopathology results, there were 33 cases of chronic cervicitis, 21 cases of
CIN I, 11 cases of CIN Ⅱ, and 6 cases of CIN Ⅲ,by histological diagnosis; considering the liquid-based cytology TBS grade, there were
26 cases of WNL, 24 cases of ASCUS, 4 cases of ASC-H, 14 cases of LSIL, and 3 cases of HSIL; As for DNA quantitative cytology
several different ploidy, none was detected in 24 cases , 1 to 2 in 35 cases, 11 cases of 3 to 14 , 1 case with more than 15. The area under
the ROC curve of liquid-based cytology was 0.921 (95%CI: 0.859 - 0.983), while the area under the curve of DNA ploidy detection was
0.836 (95% CI: 0.743 - 0.929).Conclusion:Liquid-based cytology and detection of DNA ploidy screening for cervical lesions have a
high predictive value, and are worthy of clinical application. |
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