| 纪光晰 郭永红 马力 王宇 马志远 成程 刘海莉 贾战生.病毒性肝炎肝硬化并脾功能亢进的治疗进展[J].现代生物医学进展英文版,2014,14(21):4176-4179. |
| 病毒性肝炎肝硬化并脾功能亢进的治疗进展 |
| Advances in Therapy of Hepatitis c Cirrhosis with Hypersplenism |
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| DOI： |
| 中文关键词: 脾功能亢进 外科治疗 介入治疗 |
| 英文关键词: Hypersplenism Surgical treatment Interventional therapy |
| 基金项目:国家自然科学基金项目（81170389） |
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| 中文摘要: |
| 病毒性肝炎肝硬化合并脾功能亢进是临床上常见的肝脏疾病，其产生的脾脏肿大占位效应和血细胞过度消耗及伴随骨髓
移植等临床综合症状，严重影响了针对病毒性肝炎肝硬化的抗病毒治疗。目前通过非手术治疗难以控制脾脏肿大，且无特异性药
物有效遏制，极易造成重度贫血和血小板减少症导致的出血现象，此时外科和介入治疗手段则为首选方式，一般包括脾脏切除、
脾脏部分切除、介入治疗（目前以脾动脉栓塞为主）等，其中又以脾脏切除术疗效最直接和确切。然而脾切除对人体免疫功能的损
害使人们认识到保脾的重要性，但如何最大限度的保留脾组织和脾功能，至今争议仍然存在。因此，本文综述了肝硬化脾功能亢
进的发病原因及机制，脾亢的诊断标准以及脾功能亢进的外科和介入治疗方法，为脾功能亢进的研究提供一定的理论基础。 |
| 英文摘要: |
| Spleen hyperthyroidism caused by viral hepatitis and cirrhosis is a common clinical liver disease, it often leads to
enlarged spleen, excessive consumption of blood cells, bone marrow transplantation and other clinical syndrome, seriously influences the
anti-viral therapy against viral hepatitis. Currently, non-surgical treatment is difficult to control the enlargement of the spleen, and there
are no specific drugs available, result in bleeding by severe anemia and thrombocytopenia. Compared with non-surgical treatment, the
surgical and interventional treatment, including splenectomy, spleen resection, intervention (splenic artery embolization), is more direct
and exact, especially of splenectomy. However, splenectomy is harmful to the immune function, it makes people aware of the importance
of spleen-preserving, but there are still disputes on how to maximize the retention of the spleen and splenic function. Here, we would first
review the causes and mechanisms of hypersplenismin liver cirrhosis, then discuss the diagnostic criteria and treatment of hypersplenism,
thus provide a theoretical basis for hypersplenismstudy. |
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