| 刘旭 刘静 丁嘉祥 张东亮 刘文虎.蛋白结合尿毒症毒素及其清除技术的研究进展[J].现代生物医学进展英文版,2014,14(21):4173-4175. |
| 蛋白结合尿毒症毒素及其清除技术的研究进展 |
| Progress of the Protein-bound Uremic Toxins and Removal Techniques |
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| DOI： |
| 中文关键词: 终末期肾病 蛋白结合尿毒症毒素 清除技术 |
| 英文关键词: End stage renal disease Protein-bound uremic toxins Removal techniques |
| 基金项目:国家科技支撑计划课题项目（2011BA110B02）；北京市科技计划课题项目（Z121107001012138） |
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| 中文摘要: |
| 尿毒症毒素是一大组体内代谢的产物，在肾功能衰竭患者体液中水平明显升高，并与尿毒症毒素代谢紊乱或临床表现密切
相关。部分毒素可与蛋白结合，形成大分子复合物，称为蛋白结合毒素。它们具有多种生物学作用，产生一系列尿毒症并发症，如
心血管疾病、免疫功能紊乱、脏器纤维化等。研究发现：血浆分离吸附、高通量血液透析、服用肠道吸附剂等方法可增加蛋白结合
毒素的清除。评价尿毒症患者的透析充分性时，也应考虑到蛋白结合毒素。 |
| 英文摘要: |
| Uremic toxins are a large group of metabolites, which have significantly higher levels in body fluids of renal failure
patients, and are related with toxins metabolic disorders and clinical manifestations closely. Some of them can combine with protein, to
form macromolecular complexes, which are called protein-bound uremic toxins. They have a variety of biological effects, to produce a
series of uremic complications, such as cardiovascular disease, immune dysfunction, and organ fibrosis. Researchers found that plasma
separation adsorption, high-flux hemodialysis, and taking intestinal adsorbents can increase the clearance of protein-bound uremic toxins.
While evaluating dialysis adequacy in uremic patients, protein-bound uremic toxins should also be taken into account. |
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