| 杨华强 李红 胡明均 李玉玲 覃骏 鲍红霞 吕晓娟.脐带间充质干细胞辅助治疗难治性类风湿性关节炎的临床观察[J].现代生物医学进展英文版,2014,14(21):4137-4139. |
| 脐带间充质干细胞辅助治疗难治性类风湿性关节炎的临床观察 |
| Clinical Observation on the Umbilical Cord Mesenchymal StemCells in theAdjuvant Treatment of Refractory Rheumatoid Arthritis |
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| DOI： |
| 中文关键词: 干细胞移植 难治性类风湿性关节炎 治疗 脐带间充质干细胞 |
| 英文关键词: Stemcell transplantation Rheumatoid arthritis Treatment Umbilical cord mesenchymal stemcells |
| 基金项目: |
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| 中文摘要: |
| 目的：观察脐带间充质干细胞辅助治疗难治性类风湿性关节炎的疗效和安全性。方法：将细胞总数为(5～7)× 107 个脐带间
充质干细胞通过静脉输注途径移植到自愿接受干细胞移植的2 例难治性类风湿性关节炎患者体内，4 次为1 个疗程，每次间隔1
周。治疗后随访1 年定期观察患者临床症状及各项生化和免疫学指标的变化并进行综合分析。结果：脐带间充质干细胞辅助治疗
后1 月余，2 例患者的临床症状明显改善，28 个关节的疾病活动度评分(DAS-28)由3.6 和4.0 分别降低为2.2 和2.6，血沉、C 反应
蛋白水平和类风湿因子抗体滴度也较治疗前明显降低。随访1 年余未观察到与治疗有关的副作用，并且症状持续缓解无复发。结
论：脐带间充质干细胞辅助治疗可缓解难治性类风湿性关节炎的临床症状，且未观察到与治疗有关的副作用，安全性好，值得临
床进一步研究其远期疗效。 |
| 英文摘要: |
| Objective:To observe the clinical effect and safety of UC-MSC (umbilical cord mesenchymal stem cells, UC-MSC)
transplantation in the adjuvant treatment of refractory rheumatoid arthritis.Methods:Two patients with refractory rheumatoid arthritis
were received UC-MSC transplantation (4 times as a course of treatment which every time interval one week ) with total cellular number
of UC-MSC was 5～7× 107 by intravenous infusion. Both patients were followed up regularly for one year after transplantation. Clinical
symptoms and various biochemical and immunological index were observed and literature review was performed.Results:After transplantation,
the clinical symptoms of both patients improved obviously. After transplantation, DAS-28 score of 28 arthrosis of 2 patients
decreased from 3.6 and 4.0 to 2.2 and 2.6 respectively. There were significant reduction in ESR, CRP level and RA antibody titer at 1
months after transplantation than those pre-treatment. No significant difference was observed when compared post-treatment with
pre-treatment of biochemical parameters, which contains blood routine, hepatic function, renal fuction, serum immunoglobulin, complement
C3/C4. Both patient's condition was continously catabatic and no recurrence was found after one year was followed up.Conclusion:The UC-MSC transplantation could ameliorate clinical manifestations and delay progression of rheumatoid arthritis. It was convenient,
safe and effective in the treatment of refractory rheumatoid arthritis, but further observation was still required to evaluate its long term efficacy. |
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