| 刘远杨 伊西才 龙乾发 汪凯 罗强 樊才瑞 刘卫平.LRIG2 蛋白在人催乳素腺瘤细胞中的表达研究[J].现代生物医学进展英文版,2014,14(21):4038-4040. |
| LRIG2 蛋白在人催乳素腺瘤细胞中的表达研究 |
| Expression of LRIG2 Protein in Cultured Primary Cells of HumanProlactin Adenomas |
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| DOI： |
| 中文关键词: 垂体腺瘤 LRIG2 U87 原代细胞 |
| 英文关键词: Pituitary adenomas LRIG2 U87 Primary cells |
| 基金项目: |
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| 中文摘要: |
| 目的：明确LRIG2蛋白在人催乳素腺瘤细胞中的表达与定位。方法：采用免疫细胞化学方法检测LRIG2 蛋白在人催乳素腺
瘤原代细胞中表达情况，人胶质瘤细胞系U87细胞设为阳性对照。结果：LRIG2 蛋白在原代培养的人催乳素腺瘤细胞中高表达
(86.6± 2.15)%，与其在U87 细胞中表达率无明显统计学差异；同时免疫细胞化学结果提示LRIG2 蛋白在人催乳素腺瘤细胞中定
位于胞浆，也与其在U87 细胞中表达一致。结论：LRIG2 蛋白在人催乳素腺瘤细胞中高表达，定位于胞浆，提示其可能在垂体腺瘤
发生、发展过程中发挥作用，为进一步研究垂体腺瘤发生机制奠定基础。 |
| 英文摘要: |
| Objective:To detect the expression of LRIG2 protein in human prolactin adenomas.Methods:A total of 10 samples of
surgically removed from human pituitary adenomas and clinical data were collected from Depatement of Neurosurgery in Xijing
Hospital. Immunocytochemistryand immunofluorescence staining was employed to detect the expression of LRIG2 in cultured primary
prolactin adenomas.Results:LRIG2 expresses strongly positive in U87 cells, located in cytoplasm. And LRIG2 expresses in part of
pituitary adenoma primary cells, located in cytoplasm. This has been confirmed by immunofluorescence staining.Conclusion:The
strong positive expression prompts that LRIG2 may play an important role in pituitary adenoma. It lays the foundation of the following
study. |
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