| 宋明芮1 盖大伟2 张晓云1 成慧1 张煦1△.抑癌基因DLC-1 的研究进展*[J].现代生物医学进展英文版,2014,14(20):3970-3972. |
| 抑癌基因DLC-1 的研究进展* |
| The Research Progress of DLC-1* |
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| DOI： |
| 中文关键词: 肝癌缺失基因1 基因甲基化 信号通路 肿瘤治疗 |
| 英文关键词: DLC-1 Gene methylation Signal pathway Oncotherapy |
| 基金项目:国家自然科学基金项目（31270532） |
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| 中文摘要: |
| 摘要：DLC-1(肝癌缺失基因1)是近年来被发现的一种重要的抑癌基因，目前研究发现其在多种肿瘤的发生、发展过程中产生了重
要的作用。随着基因技术及分子生物技术的飞速发展,关于DLC-1 基因以及与之相关的上、下游靶基因，DLC-1 基因的甲基化修
饰及其相互作用的信号传导通路的研究将更深入、更彻底、更清楚。通过构建肿瘤动物实验模型，我们可以对人类各种肿瘤进行
去甲基化药物治疗,分析实验结果，综合评估治疗指征，为临床上对肿瘤的治疗提供理论基础及实践指导。相信在不久的将来，针
对DLC-1 基因在肿瘤分子生物学研究有望成为多种肿瘤诊断、治疗的突破。 |
| 英文摘要: |
| ABSTRACT:DLC-1 (deleted in liver cancer-1) is discovered as an important tumor suppressor gene in recent years. Present study
finds it plays an important role in the occurrence and development of many kinds of tumors. With the rapid development of gene
technology and molecular biotechnology, the research to gene methylation modification and interaction of signaling pathways about
DLC-1 gene as well as the related upstream or downstream target genes will be deeper, more thoroughly and clearly. It can provide us
theoretical basis and practice guidance of clinical treatment to tumor so that we could take various human tumor methylation drug
treatment, analyze experimental results and take the comprehensive evaluation of treatment indications by building up tumor animal
experimental model. It is believed that the research aiming at DLC-1's molecular biology will be a breakthrough of varieties of tumors in
diagnosis and therapy. |
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