| 闫海清1 岳学静2 李晶3 李燕4 张平1.阿托伐他汀钙联合阿司匹林治疗短暂性脑缺血发作的疗效
及对颈动脉粥样硬化斑块和血脂水平的影响研究[J].现代生物医学进展英文版,2014,14(20):3931-3934. |
| 阿托伐他汀钙联合阿司匹林治疗短暂性脑缺血发作的疗效
及对颈动脉粥样硬化斑块和血脂水平的影响研究 |
| Efficacy of Atorvastatin CalciumCombined with Aspirin in Treatmentof Transient Ischemic Attacks and its Effects on Carotid AtheroscleroticPlaques and Blood lipid Levels |
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| DOI： |
| 中文关键词: 阿托伐他汀钙 阿司匹林 短暂性脑缺血 颈动脉粥样硬化 血脂 |
| 英文关键词: Atorvastatin calcium Aspirin Transient cerebral ischemia Carotid atherosclerosis Lipids |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：探讨阿托伐他汀钙联合阿司匹林对短暂性脑缺血发作的治疗疗效及其对颈动脉粥样硬化斑块和血脂水平的影响。方
法：选择我院80 例短暂性脑缺血发作患者，按入院顺序随机平均分为两组，研究组40 例患者给予阿托伐他汀钙联合阿司匹林治
疗，对照组40 例患者仅使用阿司匹林治疗。比较两组患者治疗后的治疗有效率，6 个月后分别对两组患者颈动脉粥样硬化斑块及
血脂水平进行检测。结果：研究组患者治疗总有效率为92.5%，明显高于对照组75%，比较差异具有统计学意义（P＜0.05）；治疗6
个月后研究组患者IMT 及斑块面积较治疗前明显降低，且降低程度明显高于对照组，比较差异具有统计学意义（P＜0.05）；研究
组血清中LDL、TC、TG水平较治疗前显著下降，且下降程度明显高于对照组，同时HDL 水平显著上升，而上升程度也明显高于
对照组，比较差异具有统计学意义（P＜0.05）。结论：阿托伐他汀钙联合阿司匹林对短暂性脑缺血发作的治疗疗效显著，可明显减
轻或消除颈动脉粥样硬化斑块并明显降低血脂水平，值得推广应用。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the efficacy of atorvastatin calcium combined with aspirin in treatment of transient ischemic
attacks and its effects on carotid atherosclerotic plaques and blood lipid levels. Methods：80 cases of patients with transient ischemic
attacks in our hospital were randomly divided into two groups according to the order of admission. The study group was treated with
atorvastatin calcium in combination with aspirin while the control group of 40 patients used aspirin only. Efficiency of two groups was
compared after the treatment and carotid atherosclerotic plaque and lipid levels were detected respectively after 6 months.Results： The
total effective rate of the study group was 92.5% significantly higher than 75% of the control group, the difference was statistically
significant (P<0.05); 6 months later after treatment the study group's IMT and plaque area were significantly reduced, and they were
significantly higher than the control group, the difference was statistically significant (P<0.05); The study group's serum LDL, TC, TG
levels were significantly decreased as compared with before and the degree of decline was significantly higher than that of the control
group. Meanwhile, the HDL levels of study group was significant increased, and the difference was statistically significant (P<0.05).
Conclusion:Atorvastatin calcium combined with aspirin has a significant therapeutic effect on transient ischemic attack. It could
significantly reduce or eliminate atherosclerotic plaque in the carotid artery and significantly reduce blood lipid levels, so it should be
widely applied. |
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