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摘要目的：探索老年良性前列腺增生夜尿病因特点及相关因素。方法：选取49~84 岁年龄段并已明确诊断为前列腺增生（BPH）的男性患者及没有进行过治疗或服用药物者120 例。所有患者按照IPSS评分中夜尿频率从0~5 分为6 组，记录和测量研究对象的各项指标，包括国际前列腺症状评分（IPSS）、生活质量（QOL）、剩余尿量（PVR）、最大尿流率（Qmax）、前列腺体积（TPV）和排尿量（V）。结果：夜尿频率为0~1次者共38 例（31.7%），平均QOL评分为2.43；夜尿频率为2~3 次者共50 例（41.7%），平均QOL评分为3.87；夜尿频率为4 次以上者共32 例（26.7%），平均QOL 评分为5.23。不同组的夜尿频率BPH 患者间的QOL 评分具有显著性差异（P＜0.05）；多因素Logistic 回归分析表明，BPH 患者的年龄和PVR是夜尿频率增高的危险因素(P<0.05)，而TPV 和Qmax 与夜尿频率的关系无统计学意义（P>0.05）。结论：夜尿频率的增多明显影响老年人的生活质量，并且随着老年人的年龄、残余尿量的增加，夜尿频率出现增加的趋势；但前列腺的体积和最大尿流率与夜尿频率无关。

英文摘要:

ABSTRACT Objective:To study the etiology and relative factors of nocturia in elder patients with benign prostatic hyperplasia (BPH). Methods:49-84 years old patients with confirmed BPH and without any previous treatment were selected. 120 cases were included, and they were assigned into 6 groups according to International Prostate Symptom Score (IPSS). IPSS score, quality of life (QOL), post void residual (PVR), maximumurinary flow rate (Qmax), prostate volume (TPV) and voided volume (V) were measured and recorded. Results:38 cases (31.7%) had 0-1 times nocturia, and their average QOL score was 2.43; 50 cases (41.7%) had 2-3 times nocturia, with average QOL score of 3.87; 32 cases (26.7%) had 4-5 times nocturia, with average QOL score of 5.23. Significant differences were found in QOL of different groups (P <0.05); Multivariate Logistic regression analysis showed that age and PVR was impact factors to nocturia frequency in BPH patients (P <0.05), while no relationship was found in TPV, Qmax and nocturia frequency （P>0.05）. Conclusion:The increasing nocturia frequency had obvious impact on QOL of elderly patients. With the age growth and residual urine volume increases, nocturia frequency trend to increase. However, no relationship was found in prostate volume and maximumurinary flow rate.

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