| 陈菲1 王者令2 高蕊1 刘中景2.抗病毒治疗对慢乙肝相关致癌因素的干预研究[J].现代生物医学进展英文版,2014,14(20):3909-3913. |
| 抗病毒治疗对慢乙肝相关致癌因素的干预研究 |
| The Study of Intervention of Antiviral Therapy to ChronicHepatitis B-Related Carcinogens |
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| DOI： |
| 中文关键词: 原发性肝癌 慢性乙型肝炎 危险因素 抗病毒治 |
| 英文关键词: Hepatocellular carcinoma Chronic hepatitis B Risk factors Antiviral therapy |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：研究抗病毒治疗对原发性肝癌的慢性乙型肝炎相关危险因素的干预作用。方法：回顾性分析青岛市传染病医院2010
年2 月至2012 年6 月住院的原发性肝癌患者病例249 例，经统一编制的调查表记录相关数据，分析比较抗病毒治疗组与无抗病
毒治疗组两组间各因素的分布差异。结果：抗病毒治疗组与无抗病毒治疗组患者被诊断为HCC 前的HBV感染时间、肝硬化史以
及HBV DNA 载量，P<0.05，差异均有统计学意义；两组间的HBV感染模式、AFP、CEA差异无统计学意义；相关肝功能指标经统
计学处理差异均有意义。结论：抗病毒治疗可以明显降低慢乙肝相关致癌因素在患者中的分布，有效抑制HBV DNA复制，进而
或可降低乙肝相关性肝癌的发病率。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the intervention of antiviral therapy on the risk factors of chronic hepatitis B-related hepatocellular
carcinoma. Methods:249 hospitalized cases of hepatocellular carcinoma in Qingdao Infectious Diseases Hospital from February
2010 to June 2012 were retrospectively analyzed. The relevant data recorded on the questionnaire prepared by the unified was used to
compare the distribution of various factors between antiviral treatment group and no-antiviral treatment group.Results： The differences of
time of HBV infection and that of cirrhosis before diagnosed with HCC, and HBV DNA level between antiviral treatment group and
no-antiviral treatment group were statistically significant, P<0.05; HBV infection patterns, AFP, CEA had no significant differences
between the two groups. Differences of related indicators of liver function were statistically significant.Conclusion： Antiviral therapy
could significantly reduce the percentage of the carcinogenic factors associated with chronic hepatitis B in patients, and it can effectively
inhibit the replication of HBV DNA, which maybe reduce the incidence of HBV-related HCC. |
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