Article Summary
张伟王蓁△ 林伟王翔宇江金潇.子宫内膜癌组织中uPA 及Cath-D的表达及意义[J].现代生物医学进展英文版,2014,14(20):3891-3895.
子宫内膜癌组织中uPA 及Cath-D的表达及意义
Expression and Clinical Significance of uPA and Cath-Din Endometrial Carcinoma
  
DOI:
中文关键词: 子宫内膜肿瘤  尿激酶型纤溶酶原激活剂  组织蛋白酶D  免疫组化
英文关键词: Endometrial neoplasms  Urokinase-type plasminogen activator  Cathepisn D  Immunohistochemistry
基金项目:
Author NameAffiliation
ZHANG Wei, WANG Zhen, LIN Wei,WANG Xiang-yu, JIANG Jin-xiao 青岛大学医学院附属医院妇科山东青岛266003 
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中文摘要:
      摘要目的:检测子宫内膜癌组织中尿激酶型纤溶酶原激活物(uPA)及组织蛋白酶(Cath-D)的表达并探讨相关性及其临床意义。方 法:采用免疫组织化学方法(PV-6000 二步法)检测31 例子宫内膜癌组织(内膜癌组),17 例子宫内膜增生组织(增生组)及10 例 正常子宫内膜组织(对照组)中uPA 及Cath-D 的表达,并研究其相关性。结果:1.内膜癌组中uPA 和Cath-D的表达均高于增生组 及对照组中的表达,差异均有统计学意义(P<0.05);在增生组中的表达与对照组差异无统计学意义(P>0.05)。2. uPA 和Cath-D 的 阳性表达与子宫内膜癌的临床病理分期、组织学分级及肌层浸润深度有关,差异均具有统计学意义(P<0.05)。3.内膜癌组中uPA 与Cath-D 的表达呈正相关(r=0.673,P<0.05)。结论:uPA 和Cath-D 在子宫内膜癌发生发展及侵袭转移过程中起着协同作用, Cath-D 可诱导产生活化的uPA,促进癌细胞的浸润转移,因此,两者的联合检测可有助于成为判断子宫内膜癌的发展及预后的重 要指标。
英文摘要:
      ABSTRACT Objective:To investigate the expression of urokinase-type plaminogen activator (uPA) and cathepsinD (Cath-D) in endometrial carcinoma and the correlation of the expression with clinical pathological feature of endometrial carcinoma.Methods: Ten cases of normal endometrium specimens, 17 cases was endometrium hyperplasia tissues, and 31 cases of endometrial cancer specimens, were analyzed using immunohistochemistry. The relationships among uPA and Cath-D in the endometrial cancer were analyzed by X2 test, Fish's exactly test and Pearson test. Results:The positive expression rates of uPA and Cath-D in the endometrial carcinoma tissue were significantly higher than those of the endometria1 hyperplasia tissue and the normal endometrial one's respectively(P<0.05). There's no significance between the endometrial hyperplasia and the normal one's in the expression of uPA and Cath-D. The expression of uPA and Cath-Dvaries according to the disease stage, histological grade and myometrial invasion of endometrial carcinoma (P<0.05). Cath-D positive cases were significantly positively correlated with uPA positive cases (r=0.673, P<0.05).Conclusion: The interaction between uPA and Cath-D plays a coordination role in the invasion and metastasis endometrial carcinoma. Cath-D can promote uPA in the process of invasion and metastasis, so uPA and Cath-D may be important indexes to predict the prognosis of endometrial carcinoma.
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