| 王博文1，2 吴子祥1 温鑫鑫1 严亚波1 雷伟1△.不同含湿率及加载条件对人皮质骨纳米压痕测试的影响[J].现代生物医学进展英文版,2014,14(20):3823-3827. |
| 不同含湿率及加载条件对人皮质骨纳米压痕测试的影响 |
| The Effects of Loading Conditions and Specimen Moisture Contenton the Nanomechanical Response of Human Cortical Bone |
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| DOI： |
| 中文关键词: 纳米压痕 含湿率 加载条件 弹性模量 皮质骨 |
| 英文关键词: Nanoindentation Moisture content Loading condition Indentation modulus Cortical bone |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：探讨不同含湿率及加载条件对人皮质骨纳米压痕测试的影响。方法：采用美国Hysitron 纳米压痕仪，设定不同加载模
式(高峰载荷分别为300、400、500 nm；加载速度分别为6、8、10 nm/s)对不同含湿率(20 ‰、30 ‰、40 ‰、50 ‰、60 ‰)人皮质骨进行
弹性模量及硬度测量。结果：在同一加载模式下，不同含湿率标本的测试值随着含湿率增高，弹性模量及硬度值均显著降低
(P<0.01)；三种不同加载模式对含湿率为20 ‰标本测试值无明显变化；对含湿率60 ‰标本测试值有显著性影响(P<0.02)。结论：
纳米压痕仪测试骨微观力学特性时，测试值不仅受标本本身含湿率的影响，当测试条件改变，对湿润标本测试结果也完全不同。
当使用纳米压痕技术时，通常采用脱水包埋处理的标本测试出的机械性能，对我们在微观层面认识人体骨在湿润的生理环境下
的机械性能是不够全面的。 |
| 英文摘要: |
| ABSTRACT Objective:To explore the influence of distinct moisture percentages and loading conditions on the nanoindentation
measurement in human cortical bones.Methods: Elastic modulus and hardness of human cortical bones that contain different moistures
(20‰, 30‰, 40‰, 50‰ and 60‰) were measured with the Hysitron nano indentation tester in different loading modes (peak loads of
300, 400 and 500 nmrespectively, loading rates of 6, 8 and 10 nm/s respectively).Results: Under the same load condition, for specimens
of different moisture percentages, the values measured rose and elastic modulus and hardness values lowered with the increasing moisture
percentages (P<0.01); the three different loading modes had little influence on values measured in the specimen with 20‰ moisture
percentage, but significant influence on values measured in the specimen with 60‰ moisture percentage (P<0.02). Conclusion:When
micromechanical properties of bones were measured with the nanoindentation tester, the values measured were affected by the moisture
percentage of the specimen itself; in addition, when the test conditions were changed, the test results of moist specimens were completely
different, which showed that the mechanical properties obtained from the specimens generally undergone dehydration and encapsulation
treatment with nanoindentation technique were not comprehensive enough for our understanding about the mechanical properties of
human bones under moist physiological environment at the micro level. |
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