| 侯进军 邓齐文 孙慧玲 陈杰 刘贤 王书奎.生化指标与2 型糖尿病患者实验诊断及预后相关性研究[J].现代生物医学进展英文版,2014,14(19):3651-3656. |
| 生化指标与2 型糖尿病患者实验诊断及预后相关性研究 |
| Study on Association of Biochemical Criterion and Laboratory Diagnosiswith Related Prognosis in Type 2 Diabetic Patients |
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| DOI： |
| 中文关键词: 2 型糖尿病 BMI 糖化血红蛋白 肥胖 |
| 英文关键词: Type 2 diabetes Body mass index Glycated hemoglobin Obesity |
| 基金项目:国家自然科学基金项目（81172141） |
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| 中文摘要: |
| 目的：研究BMI、HbA1c、病程、相关代谢指标与2 型糖尿病（T2DM）诊断及预后的关系。方法：收集379 例T2DM 患者与
383 例健康体检者，采用生化分析仪分析二组人群的生化指标，采用高效液相色谱法检测T2DM 组HbA1c 水平，胰岛素及C 肽
采用电化学发光法检测。计量资料采用t 检验、单因素方差及相关性分析，计数资料采用卡方检验分析。结果：对各组结果进行比
较显示（1）T2DM 患者的BMI、FBG、TG、LDL-C、BUN、UA、HbA1c 水平明显高于正常对照组（P均<0.01)，HDL-C、CREA 水平明
显低于对照组（P均<0.01)；（2 ）TC、LDL-C、BUN、CREA及2hINS 与年龄相关。（3）肥胖组的TG、CREA、UA、FCP、2hCP 高于非肥
胖组（P 均<0.05)；（4 ）初诊T2DM 患者的FBG、TG、HbAlc、LDL-C 水平明显高于5 年以上患者（P均<0.05)，而HDL-C 低于5 年
以上患者（P<0.05)；（5 ）HbA1c≥ 11%组的FBG水平明显高于HbA1c≤ 8%及HbA1c＝8～11%组（P<0.01），而UA、FINS、FCP、
2hINS、2hCP 水平明显低于HbA1c<8%组（P 均<0.01)；FBG、TG 与HbA1c 水平呈正相关（P<0.05）；FINS、FCP、2hINS、2hCP、UA
与HbA1c 水平呈负相关（P<0.01)；结论：BMI、FBG、TG、LDL-C、BUN、UA、HDL-C、CREA均可作为T2DM诊断的参考指标。其中
LDL-C、BUN、CREA、2hINS 指受年龄影响。TG、CREA、UA、FCP(空腹C-肽）、2hCP与肥胖相关。FBG、TG、HbAlc、LDL-C、HDL-C
与病程相关；FBG、TG、HbA1c、FINS、FCP、2hINS、2hCP、UA与HbA1c 相关。 |
| 英文摘要: |
| Objective:To investigate the relationship among different body mass index (BMI), hemoglobinA1C (HbAlc),
different courses of disease, related metabolic indicators in the diagnosis and prognosis of type 2 diabetic mellitus.Methods:379 type 2
diabetes patients and 383 normal healthy people were randomly divided into two groups. HbAlc was detected with high performance
liquid chromatography in type 2 diabetic patients. The Roche COBAS-e601 electrochemical luminescence instrument was used to
determine the levels of insulin and C-peptide. Measurement data were compared by using T-test, ANOVA and pearson correlation
analysis, and chi-square test was used for the count data.Results:(1)The levels of BMI, FBG, TG, LDL-C, BUN, UA, HbA1c in the
patients group were significantly higher than that in the normal group（P<0.01), and the levels of HDL-C and CREA were lower than that
in normal group（P<0.01). (2)The level of TC, LDL-C, BUN, CREA and 2hINS were related with age. (3)The levels of TG, CREA, UA,
FCP（fasting C peptide) and 2hCP in the obese group（BMI ≥ 25）were higher than that in non-obese group（BMI<25）(P<0.05). (4)The
levels of FBG, TG, HbAlc and LDL-C in the newly diagnosed patients (<1 year) were significantly higher than those in the group with
the course of disease beyond 5 years.(P<0.05), and HDL-C levels were lower than those in the group with the course of disease beyond 5
years（P<0.05). (5)The levels of FBG in the group with HbA1c≥ 11%was higher than that in the group with HbA1c≤ 8 and in the group
with HbA1c8～11%（P<0.01）, and the levels of UA, FINS, FCP, 2hINS, 2hCP were significantly lower than that in the group with
HbA1c<8%(P<0.01). Pearson correlation analysis shows that FBG and TG have positive correlation with HbAlc (P<0.05）, and FINS,
FCP, 2hINS, 2hCP and UA showed a significant negative correlation with HbAlc (P<0.01).Conclusion:The levels of BMI, FBG, TG,
LDL-C, BUN, UA, HDL-C, CREA could be regarded as the reference indicators for the diagnose, and LDL-C, BUN, CREA, 2hINS were
influenced on age. TG, CREA, UA, FCP (fasting C-peptide) and 2hCP were related with obesity. The course of disease could change the
levels of FBG, TG, HbAlc, LDL-C, HDL-C. Therefore, the levels of FBG, TG, HbA1c, FINS, FCP, 2hINS, 2hCP and UA were
associated with HbA1c. |
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