| 杨德华 郭晓东 余灵祥 周艳贤 杨美 熊璐 李志伟.XIAP及survivin 在原发性肝细胞癌组织中的表达及其相关性研究[J].现代生物医学进展英文版,2014,14(18):3426-3428. |
| XIAP及survivin 在原发性肝细胞癌组织中的表达及其相关性研究 |
| Study on the Expression and Crrelation of XIAP and Survivin in PrimaryHepatocellular Carcinoma (HCC) |
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| DOI： |
| 中文关键词: 原发性肝细胞癌 X 连锁凋亡抑制蛋白 survivin 相关性 |
| 英文关键词: Primary hepatocellular carcinoma X-linked apoptosis inhibiting protein Survivin Correlation |
| 基金项目:四川省中医药管理局课题（2010-39） |
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| 中文摘要: |
| 目的：探讨X 连锁凋亡抑制蛋白（XIAP）和survivin 在原发性肝细胞癌中的表达及两者的相关性。方法：选取本院收治的60
例原发性肝细胞癌患者，应用免疫组织化学染色的方法对肝癌组织及癌旁组织中的XIAP及survivin 的表达进行检测。结果：经
比较，肝癌组织中XAIP 及survivin 的阳性率均显著高于癌旁组织，差异有统计学意义。XIAP 和survivin 的表达强度与肿瘤的大
小无关，但随肿瘤的分化程度的降低而升高，且不同分化程度之间差异有统计学意义；XIAP 和survivin 存在正相关关系。结论：
XIAP与Survivin 在肿瘤组织中的高表达在促进肿瘤发生、增殖、转移以及耐药，并且能够降低肿瘤的分化程度，增加肝癌的恶性
程度。此外，两者可能存在协同作用，但两者的相关性及作用机制仍需进一步探讨。 |
| 英文摘要: |
| Objective:To explore the expression and correlation of XIAP and survivin in primary hepatocellular carcinoma
(HCC).Methods:60 patients with HCC treated in our hospital were selected, and the expression of XIAP and survivin in HCC tissues
and adjacent mucosa were detected by immunohistochemistry staining.Results:Comparatively, the positive rate of XAIP and survivin in
HCC tissues were significantly higher than that of adjacent mucosa, the difference was statistically significant. The expression intensity of
XIAP and survivin had nothing to do with the tumor size, but it expressed highly with the decrease of differentiation degree of tumor, and
the differences between different differentiation degree were statistically significant; positive correlation existed between XIAP and
survivin.Conclusion:High expression of XIAP and survivin in tumor tissues can promote the incidence, proliferation, metastasis and
drug resistance of tumor, as well as reduce the tumor differentiation degree, increase the malignant grade of liver cancer. In addition,
there are possible synergies between XIAP and survivin, but their correlation and mechanismneeds further exploration. |
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