| 杨金有 俞航 刘静 洪洋.椎动脉狭窄内血液两相流动数值模拟分析[J].现代生物医学进展英文版,2014,14(18):3410-3413. |
| 椎动脉狭窄内血液两相流动数值模拟分析 |
| Numerical Simulation in two-phase Blood Flow in Stenosisof Vertebral Artery |
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| DOI： |
| 中文关键词: 两相流 椎动脉 血流动力学 计算流体力学 |
| 英文关键词: Two-phase blood flow Vertebral artery Hemodynamics Computational fluid dynamics |
| 基金项目:国家自然科学基金项目（G81273511） |
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| 中文摘要: |
| 目的：对应用三维重构得到的人体真实椎动脉进行血液两相流数值模拟，与经典单相流牛顿血液模型对比，分析动脉粥样
硬化等病因与椎动脉狭窄处的血流动力学关系。方法：把考虑血细胞和血浆的两相流血液模型应用到逆向工程方法构建的基于
人体生理解剖特征的椎动脉三维几何模型中去进行数值模拟，分析血细胞分布情况等血流动力学参数，并与单相流模型的模拟
结果进行对比。结果：通过瞬态模拟计算，得到了椎动脉在心动周期内不同时刻的两相流和单相流模型的血流动力学参数。结论：
通过对比单相流数值模拟结果，得出血管狭窄处血细胞出现聚集，血流更加复杂和低壁面切应力分布等与动脉粥样硬化及血栓
的形成相关的结论。并且与两相流模型相比，单相流模型存在如无法获得如血细胞分布等不足，为进一步深入研究椎动脉等疾病
的发病机理提供方法和理论支持。 |
| 英文摘要: |
| Objective:Applied three-dimensional reconstruction of the human to get to simulate blood flow in vertebral artery
based on two-phase blood model, and compared with the classic Newtonian model of single-phase flow to analysis the relationship
between hemodynamic and vertebral artery stenosis causes such as atherosclerosis and so on.Methods:The blood was considered
two-phase blood model with blood cells and blood plasma. Applied this blood model to simulate blood flow in three-dimensional geometric
model of vertebral artery based on reverse engineering methods, and analysis hemodynamic parameters such as blood cell distribution.Results:Through transient calculation, obtained the hemodynamic parameters of the vertebral artery at different time during a cardiac
cycle of two-phase flow model and single- phase flow.Conclusion:Comparing and analyzing the results of single-phase model and
two-phase model, blood cells appear clustered, more complex blood flow and low wall shear stress distribution maybe cause atherosclerosis
and thrombosis. And compared with the two-phase model, single-phase model is not enough for research such as no blood cells distribution. |
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