| 王媛媛王明光姚丹黄秀秀张桐.托吡酯与苯巴比妥对小儿癫痫患儿发作次数及痫样放电的影响对比[J].现代生物医学进展英文版,2014,14(15):2918-2920. |
| 托吡酯与苯巴比妥对小儿癫痫患儿发作次数及痫样放电的影响对比 |
| Impact Comparison of Topiramate and Phenobarbital for Seizure Frequencyand EpileptiformDischarges in Children with Epilepsy |
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| DOI： |
| 中文关键词: 托吡酯 苯巴比妥 小儿癫痫 发作次数 痫样放电 |
| 英文关键词: Topiramate Phenobarbital Epilepsy Seizure frequency Epileptiformdischarges |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：研究托吡酯（topiramate，TPM）与苯巴比妥（phenobarbital，PB）对小儿癫痫（Epilepsy）患儿发作次数及痫样放电的影响。
方法：将我院2010 年8 月至2013 年8 月入院接受诊治的200 例癫痫患儿作为观察对象，随机分成两组。观察组采用TPM治疗，
对照组采用PB治疗。对比两组患儿治疗前以及治疗后3 个月癫痫发作次数、疗效以及不良反应情况。结果：观察组部分性发作减
少次数、全身性发作减少次数及总发作减少次数，均显著高于对照组；观察组治愈率、愈显率、总有效率，均显著高于对照组；观察
组不良反应情况显著少于对照组；差异均具有统计学意义（均P<0.05）。结论：与PB相比，TPM 治疗小儿癫痫疗效更佳，且不良反
应更少，值得临床推荐。 |
| 英文摘要: |
| ABSTRACT Objective:To study impact comparison of topiramate and phenobarbital for seizure frequency and epileptiform discharges
in children with epilepsy.Methods: The total of 200 cases children with epilepsy in our hospital from Aug 2010 to Aug 2013 were
randomly divided into two groups. The observation group was treated with TPMand the control group with PB，compared the seizure frequency,
efficacy and adverse reactions of two groups.Results: The reduce number of partial seizures，generalized seizures and total
seizures of observation group were significantly higher than those of the control group. The rate of cure, markedly effective, total efficiency
of observation group were significantly higher than those of the control group. The adverse reactions of observation group were significantly
lower than that of the control group. The differences were statistically significant (P<0.05).Conclusion: Compared with PB, TPM
shows better effect on epilepsy with less adverse reactions. It is worthy of recommendation. |
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