| 奚宏伟1 魏长征1△ 王文斌1 蒋丽霞1 盛爱莲1 侯春林2.壳聚糖-三聚磷酸钠纳米粒对于肝组织严重出血模型的止血效果*[J].现代生物医学进展英文版,2014,14(15):2831-2834. |
| 壳聚糖-三聚磷酸钠纳米粒对于肝组织严重出血模型的止血效果* |
| Effects of Chitosan-TPP Nanoparticles on Wound Healing of HepaticTissue after Severe Bleeding* |
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| DOI： |
| 中文关键词: 壳聚糖 纳米粒子 肝损伤 伤口愈合 止血 |
| 英文关键词: Chitosan Nanoparticles Hepatic injury Wound healing Hemostasis |
| 基金项目:上海科委重点科技攻关项目（09DZ1907000） |
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| 中文摘要: |
| 摘要目的：建立SD 大鼠肝脏严重出血模型，考察壳聚糖-三聚磷酸钠（TPP）纳米粒的止血效果对于实质性器官严重出血的止血
效果。方法：24 只SD 大鼠各分3组，每组8 只，分为阴性对照组、壳聚糖-TPP组（NP组）和正常组，其中阴性对照组和NP组的大
鼠建立肝脏严重出血模型。NP组，将壳聚糖-TPP 纳米粒喷射到伤口，直至将整个伤口覆盖。阴性对照组，不使用任何止血材料
处理创面。术后15 天，用SEM 和TEM 观察NP组和阴性对照组的肝组织的微观结构。结果：通过组织学检查发现壳聚糖-TPP 纳
米粒在治疗严重伤口时能加速肉芽和大量胶原蛋白的生成，这正是伤口愈合初期的标志。结论：壳聚糖-TPP 纳米粒对于严重出
血的实质器官可发挥优良的止血性能，并能促使伤口愈合。 |
| 英文摘要: |
| ABSTRACT Objective:To study the effects of chitosan-TPP nanoparticles on wound healing by building the model of severe bleeding
of SD rat's liver. Methods:24 SD rats were randomly divided into three different groups, each group included 8 rats. The rats in the
negative group and the chitosan-TPP nanoparticles group (NP group) was dealt with severe bleedingin the liver. In the NP group, the chitosan
nanoparticleswere sprayed onto the wound until the whole wound was sealed. In the negative group, the same procedure was performed
except any treatments. 15 days after operation, the microstructure of hepatic tissues in both NP group and negative group were investigated
by SEMand TEM.Results: It was found in the histological observation that new granulations and a large amount of collagens
were generated when chitosan-TPP nanoparticles was treated on the severe wound, which is one of the main signs in the early period of
wound healing. Conclusion:The chitosan-TPP nanoparticles can be an ideal material in the treatment of severe bleeding and subsequent
wound healing. |
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