| 晏昱婧胡小鹏胡艺冰夏耘吴亚群△.跨膜型TNF-α与NF-κB 在三阴性乳腺癌中的表达及其意义*[J].现代生物医学进展英文版,2014,14(15):2819-2822. |
| 跨膜型TNF-α与NF-κB 在三阴性乳腺癌中的表达及其意义* |
| The Expressions and Clinical Significances of Transmembrane TNF-alphaand Nf-kappa B in Triple Negative Breast Cancer* |
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| DOI： |
| 中文关键词: 三阴性乳腺癌 跨膜型TNF-α NF-κB 耐药 |
| 英文关键词: Triple negative breast cancer Transmembrane TNF-alpha Nf-kappa B Drug resistant |
| 基金项目:国家自然科学基金面上项目(81172512)；省自然科学基金资助项目(2011CDB558) |
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| 中文摘要: |
| 摘要目的：探讨跨膜型TNF-α与磷酸化NF-κB 在三阴性乳腺癌(TNBC)中的表达及其临床意义。方法：采用免疫组化法检测52
例三阴性乳腺癌与30 例非三阴性乳腺癌组织中跨膜型TNF-α与磷酸化NF-κB的表达，并分析其与三阴性乳腺癌各临床指标的
相关性。结果：跨膜型TNF-a 与磷酸化NF-κB 在三阴性乳腺癌中的阳性表达率分别为82.7%(43/52)和67.3%(35/52)，均显著高于
非三阴性乳腺癌，差异具有统计学意义(P<0.05)。在三阴性乳腺癌中，跨膜型TNF-α及磷酸化NF-κB 的表达与肿瘤大小和淋巴结
转移与否显著相关(P<0.05)，且跨膜型TNF-α与磷酸化NF-κB 的表达呈显著正相关(P<0.05)。结论：跨膜型TNF-α及磷酸化
NF-κB 高表达可能预示着TNBC 更差的化疗敏感性和预后，有望成为TNBC 预后的重要预测因子。跨膜型TNF-α通过激活磷酸
化NF-κB 激活其下游的抗凋亡和促增殖因子，与三阴性乳腺癌的发生发展有关。 |
| 英文摘要: |
| ABSTRACT Objective:To discuss the expressions and clinical significances of transmembrane TNF-alpha and nf-kappa B in triple
negative breast cancer. Methods:The expressions of transmembrane TNF-alpha and phosphorylated nf-kappa B in 52 cases of triple negative
breast cancer and 30 cases of non-triple negative breast cancer were detected by immunohistochemical method and their correlation
with the clinical indicators were analyzed. Results:The positive rates of transmembrane TNF-α and phosphorylated nf-lappa B in triple
negative breast cancer were 82.7%(43/52) and 67.3%(35/52), which were significantly higher than those in the non-triple negative breast
cancer. In TNBC, the expressions of transmembrane TNF-αand phosphorylated nf-kappa B were significantly positively correlated with
the tumour sizes and lymph node metastasis (P<0.05), the expressions of transmembrane TNF-α and phosphorylated nf-kappa B were
positively correlated (P<0.05).Conclusion: High expressions of transmembrane TNF alpha and phosphorylated nf-kappa B may indicate
chemotherapy resistance and worse prognosis of triple negative breast cancer. Transmembrane TNF alpha activate the antiapoptotic factors
and multiplication factors of downstreamby activating phosphorylated nf-kappa B, which is associated with the occurrence and development
of triple negative breast cancer. |
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