| 孙立 谢克亮 马亚群 潘宁玲 张宏.富氢盐水对缺血再灌注损伤保护作用的研究进展[J].现代生物医学进展英文版,2014,14(13):2580-2582. |
| 富氢盐水对缺血再灌注损伤保护作用的研究进展 |
| The Protective Effects of Hydrogen-rich Saline on Ischemia-reperfusionInjury |
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| DOI： |
| 中文关键词: 富氢盐水 缺血再灌注损伤 |
| 英文关键词: Hydrogen-rich brine Ischemia-reperfusion injury |
| 基金项目: |
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| 中文摘要: |
| 缺血是临床疾病中最常见原因之一，缺血再灌注损伤是脑缺血等器官缺血最重要病理生理过程，缺血性疾病通常可在早期
采用溶栓和抗自由基损伤等技术来防治。氢气目前仅作为保健品使用，尚未应用于临床，富氢盐水作为一种含氢注射液，能够减
少缺血再灌注损伤，减轻炎性反应，抑制细胞凋亡，减少氧化应激，从而对器官起到明确的保护作用。缺血再灌注损伤在临床发生
率极高，富氢盐水作为一种能够普及、应用方便的保护剂，具有广大的应用前景。富氢盐水用于防治缺血再灌注导致的组织损伤
和器官功能障碍的可能机制为降低氧化应激、减少细胞凋亡和抑制炎性因子上调。 |
| 英文摘要: |
| Ischemic is the most common clinical disease. Ischemia-reperfusion injury is the most important pathophysiological
processes of cerebral ischemia. Ischemic disease can usually be attenuate in the early stage by thrombolytic，anti-oxygen free radical damage
or other techniques. Hydrogen is currently used only as supplements and have not been used in clinic. Hydrogen-rich saline which
has plenty of hydrogen can be used for prevention and treatment of tissue damage and organ dysfunction induced by ischemia-reperfusion
injury. Hydrogen-rich saline can reduce ischemia-reperfusion injury and inflammation reaction, inhibit apoptosis, decreased oxidative
stress and thus plays a protective effect. Its possible mechanismmaybe reduction of oxidative stress, reduction of apoptosis and inhibition
of inflammatory factors. |
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