| 程少毅 冯征 周勇安 李小飞 祖超 王艳 卢强.新辅助化疗对局部晚期非小细胞肺癌患者术后生存质量的影响[J].现代生物医学进展英文版,2014,14(13):2465-2468. |
| 新辅助化疗对局部晚期非小细胞肺癌患者术后生存质量的影响 |
| The Effect of Neoadjuvant Chemotherapy on Quality of Life in PatientsDiagnosed with Local Advanced Non-small Lung Cancer |
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| DOI： |
| 中文关键词: 新辅助化疗 局部晚期非小细胞肺癌 生存质量 |
| 英文关键词: Neoadjuvant chemotherapy Locally advanced non-small cell lung cancer Quality of life |
| 基金项目:陕西省自然科学基金项目（2012JM4022） |
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| 中文摘要: |
| 目的：探讨新辅助化疗对局部晚期非小细胞肺癌患者术后生存质量的影响。方法：选取2011 年5 月至2012 年5 月于本院
胸腔外科接受治疗的ⅢＡ~ⅢＢ 期非小细胞肺癌患者240 例并将其随机分成2 组，即新辅助化疗组(A组)和单纯手术组(B 组)，每
组120 例。A组患者在临床确诊后接受2 个周期的新辅助化疗，化疗结束2~3 周后接受手术治疗；对照组患者临床确诊后直接行
手术治疗。术后，两组患者均给予4 周期常规放化疗。采用QLQ-C30 量表对两组患者术前与术后第1、3、6 个月的生存质量进行
评估，并比较两组患者生存质量评分的差异。结果：术后1、3、6 个月时，两组患者的各项功能分值均较术前显著升高(P<0.05)；术
后第3、6 个月，患者的总体健康状况得分较术前显著升高(P<0.05)；术后1 个月时，A组患者的呼吸困难评分较术前明显增加
(P<0.05)，术后第3 个月后，该分值与术前比较无显著性差异；术后第1、3 个月时，两组患者的疼痛评分均较术前明显升高(P<0.
05)，但第6 个月时，该评分与术前无显著性差异；术后第6 个月时，两组患者的疲乏得分较术前明显降低(P<0.05)；术后第1、3、6
个月时，两组患者的经济困难评分明显较术前升高(P<0.05)。术后1、3、6 个月时，A 组患者的总体状况得分均显著高于B 组(P<0.
05)，呼吸困难评分和疲乏评分明显低于B 组(P<0.05)，经济困难评分均显著高于B 组(P<0.05)。结论：新辅助化疗可以提高局部晚
期非小细胞肺癌患者术后半年内的生存质量。 |
| 英文摘要: |
| Objective:To explore the effect of neoadjuvant chemotherapy on quality of life in patients diagnosed with local
advanced non-small lung cancer.Methods:Selected 240 patients diagnosed with non-small cell lung cancer of ⅢＡand ⅢＢform May
2011 to May 2012 in thoracic surgery department of our hospital. The subjects were equally divided into two groups: Group A
represented patient received neoadjuvant chemotherapy and surgery treatment; Group B represented patient without neoadjuvant
chemotherapy. Patients in Group A received two cycles of neoadjuvant chemotherapy, and then received surgery treatment after 2~3
weeks. Patients in Group B only received surgery treatment. Patients in both groups were given four cycles of chemotherapy and
radiotherapy. The life quality was measured by QLQ-C30 scale before and after surgery.Results:In the first, third and sixth months after
surgery, the functional scales of both groups were significantly higher than that of pre-operation (P<0.05); In the third and sixth months
after operation, the global health status of both groups were much better when compared with pre-operation (P<0.05). For patients of
Group A, the dyspnea was more serious in the first month after operation (P<0.05), but two months later, the difference was not
significant. The pain scales of both groups were higher than pre-operation in the first and third month (P<0.05), but in the sixth month, the
pain eased significantly. In the sixth month after surgery, the fatigue scales of both group were significantly lower than that of
pre-operation (P<0.05). The global health status scales of Group A were much higher than that of Group B, while the fatigue and dyspnea
scales were lower than that of Group B, but the financial difficulties of Group A were much heavier in all observation time points than
Group B (P<0.05).Conclusion:The neoadjuvant chemotherapy could improve the quality of life in patients diagnosed with local
advanced non-small lung cancer. |
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