| 张晶 周立君 栾天竹 徐凤龙.匹伐他汀临床应用的最新进展[J].现代生物医学进展英文版,2014,14(12):2383-2386. |
| 匹伐他汀临床应用的最新进展 |
| Pitavastatin the Ting Clinical Applications Progress |
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| DOI： |
| 中文关键词: 匹伐他汀 冠心病 降血脂 |
| 英文关键词: pitavastatin Coronary heart disease lipids-lowering |
| 基金项目: |
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| 中文摘要: |
| 匹伐他汀(pitavastatin)是新一代人工合成的降血脂类药物。该药是新一代HMG-COA还原酶抑制剂，用于治疗原发型高脂
血症和混合型血脂障碍，能够显著降低LDL、TC、TG、及升高HDL-C。药物动力学性质优良，具有肝细胞选择性，并且毒性低，安
全性好，具有抗动脉粥样硬化、促进血管生成和抗炎作用。本文就匹伐他汀的临床研究进展进行综述。 |
| 英文摘要: |
| Pitavastatin is the new generation of synthetic lipid-lowering drugs. The drug is a new generation of HMG-COA reductase
inhibitor, for the treatment of the original hairstyle hyperlipidemia and mixed dyslipidemia, low-density lipoprote in cholesterol
(LDL-C), Total cholesterol(TC), triglycerides (TG), and also increase high-density lipoproteincho lesterol (HDL-C). The drug iswell tolerated
and safe. Itnotonly haspotent cholesterol-lowering effects, but also has anti-atherosclerotic, angioge-Nesis-promoting and anti-inflammatory
effects by selectively acting on liverv cells. The advancement of pitavastatin in current clinic newest researches are reviewed
in this article. |
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