| 任玉欣 赵松 付英梅 刘云力 罗娜 赵柏.miRNA-125b 在膀胱癌中的表达和意义[J].现代生物医学进展英文版,2014,14(12):2251-2254. |
| miRNA-125b 在膀胱癌中的表达和意义 |
| Expression and Clinical Significance of miR-125b in Bladder Cancer |
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| DOI： |
| 中文关键词: 膀胱癌 miR-125b 表达 意义 |
| 英文关键词: Prostate cancer MiR-125b Expression Significance |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨膀胱癌组织中miR-125b的表达在膀胱癌发生发展中的作用及其临床意义。方法：采用应用茎环RT-PCR的方法
检测66 例膀胱尿路上皮癌组织标本的miR-125b 的表达，另有16 例正常膀胱黏膜组织作对照，并结合临床病理资料进行统计学
分析。结果：miR-125b 在膀胱癌组织中的表达显著高于非肿瘤的正常膀胱黏膜组织（p<0.05），miR-125b 的水平还与表达水平与膀
胱癌的组织学分级、肿瘤转移、术后复发均明显相关性(P<0.05)。结论：miR-125b 在膀胱癌组织中表达量升高，且与组织学分级、肿
瘤转移、术后复发相关，可能作为膀胱癌诊断和预后指标。 |
| 英文摘要: |
| Objective:To investingate miR-125b expression in bladder cancer and to evaluate the potential correlations between
miR-125b expression and clinicopathologic features of bladder cancer patients.Methods:Total RNA from 66 bladder cancer tissues and
16 normal bladder tissues were extracted and analyzed form miR-125b expression by stem-loop real-time RT-PCR. The correlation
between miR-125b expression and clinicopathologic features was investigated.Results:miR-125b expression in bladder cancer tissues
was significantly increased than those in those of normal bladder tissues (P<0.05). And expression level of miR-125b was related to
histological grade, metastasis and recurrence(P<0.05).Conclusion:miR-125b has a higher expression level in bladder cancer. Expression
level of miR-125b also has a strong association with histological grade, metastasis and recurrence in bladder cancer. And it has a potential
application working as a diagnostic and prognostic indicator in bladder cancer. |
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