| 王加红 许静 苏枫 张忠 张文佳 曹清 管文琦 陆献成.卡维地洛对老年慢性心肾综合征患者血浆IL-6、IL-10水平的影响[J].现代生物医学进展英文版,2014,14(11):2122-2125. |
| 卡维地洛对老年慢性心肾综合征患者血浆IL-6、IL-10水平的影响 |
| Effects of Carvedilol On the SerumLevels of Interleukin-6 and Interleukin-10In the Elderly Patients With Cardiorenal Syndrome |
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| DOI： |
| 中文关键词: 卡维地洛 慢性心肾综合征 炎症因子 白介素-6 白介素-10 |
| 英文关键词: Cardiorenal syndrome Inflammatory factor Carvedilol IL-6 IL-10 |
| 基金项目:上海市杨浦区中心医院院级课题（SE1201019） |
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| 中文摘要: |
| 目的：观察卡维地洛对慢性心衰合并肾功能不全(CRS)患者血浆IL-6、IL-10 水平的影响。方法：将2011～2012 年我院收治
的60 例CRS 患者采用数字表分组法随机分为对照组和治疗组两组，对照组仅给予常规心力衰竭治疗，治疗组在接受常规心力衰
竭治疗的基础上加用卡维地洛直至目标剂量。治疗6个月后比较两组患者的心功能、肾功能和血浆IL-6、IL-10 的水平。结果：治疗
6 个月后，治疗组LVEDD、LVESD 较治疗前明显缩小(P<0.05)，且明显小于对照组(P<0.05)，而LVEF 比治疗前明显升高(P<0.05)，
也明显高于对照组(P<0.05)；治疗组的血浆BUN、Cr 和IL-6 水平均较治疗前显著降低(P<0.05)，且均明显低于对照组(P<0.05)，血
浆IL-10 有上升趋势，但差异无统计学意义(P>0.05)。治疗前后，对照组以上指标比较差别均无统计学意义(均P>0.05)。结论：卡维
地洛辅助治疗可显著降低CRS 患者血浆IL-6水平，对血浆IL-10 的影响不明显。 |
| 英文摘要: |
| Objective: To observe the effect of carvidilol on the serumlevel of IL-6 and IL-10 in elderly patients with cardiorenal
syndrome.Methods: 60 patients diagnosed as cardiorenal Syndrome (CRS) were enrolled in this study and divided into routine treatment
group(30 patients) and carvedilol treatment group(30 patients). After treatment with carvedilol in titrating doses and persisting doses for 6
months. left ventricular ejection fraction (LVEF)and the plasma concentrations of BUN, Cr and the serum level of IL-6, IL-10 were
measured and compared.Results:After being treated for six months, the LVEDD, LVESD were reduced significantly(P<0.05),which
were smaller than those in the control group (P<0.05), while the LVEF increased significantly (P<0.05) and was higher than that in the
control group (P<0.05). The serum BUN, Cr and IL-6 levels were reduced significantly (P<0.05) and smaller than those in the control
group (P<0.05), while the IL-10 increased slightly and there was no statical significance (P>0.05). All the indexs mentioned above in the
control group, there were no statical significance both at prior-treatment and post-treatment(P>0.05). Conclusion:Carvidilol could relieve
the systemic inflammatory reaction and increase the IL-6 level but have little effect on IL-10 in cardiorenal syndrome patients． |
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