| 毕明慧 陆钦池 杨晓岚 刘强 张韶辉.局灶性皮质发育不良的MRI表现及生活质量水平的评估[J].现代生物医学进展英文版,2014,14(11):2065-2068. |
| 局灶性皮质发育不良的MRI表现及生活质量水平的评估 |
| Evaluation of Focal Cortical Dysplasia MRI Performance and Quality of Life |
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| DOI： |
| 中文关键词: 局灶性皮质发育不良 核磁共振 生活质量 |
| 英文关键词: Focal cortical dysplasia Magnetic resonance imaging Life quality |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨局灶性皮质发育不良(FCD)与影像学改变的相关性，并应用日常生活能力量表(ADL)评价FCD 患者手术前后的
生活质量改善以及癫痫缓解率。方法：回顾性分析60 例FCD癫痫患者MRI检查，观察病变部位影像学变化；回顾60 例FCD癫
痫患者手术前后所填写的生活质量量表，分析患者总体健康水平，总体生命质量，情绪健康，日常精力，认知能力，对药物副作用
的担忧，对癫痫发作的担忧，以及社会功能的变化。结果：60 例FCD 患者有23 例（阳性率为38.3%）表现出FCD 的病理特征。这
23 例中表现有四种：灰白质交接模糊，皮层增厚，异常脑沟脑回图案，脑叶萎缩。生活质量量表显示FCD患者（术前）生活质量明
显差于正常人群，FCD患者术后的生活质量比术前得到改善。结论：FCD 患者的MRI表现呈现多样性，但主要有四种类型。FCD
患者术后生活质量得到改善，提示癫痫缓解率提高。 |
| 英文摘要: |
| Objective:To analyze the magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD), and to
investigate the life quality of FCD patients. Methods:60 patients with pathological confirmed FCD were collected in the current study to
evaluate the lesion location by MRI and to assess life quality through activity of daily living scale (ADL). Results:23 out of 60 patients
were identified to be abnormal by MRI, with the appearance of abnormal gray/white matter junction, cortex thickness, morphology of
gyri and sulci, and lobar atropy. In addition, the life quality of FCD patients was improved after surgical intervention. Conclusion:FCD
patients present multifarious MRI appearance. After surgical intervention, seizure remission rate was improved. |
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