Article Summary
章雪莲 饶丽娟 李名花 余丽辉 魏馨.复发性自然流产患者外周血中Th17 及Treg细胞及其效应因子的变化[J].现代生物医学进展英文版,2014,14(11):2055-2057.
复发性自然流产患者外周血中Th17 及Treg细胞及其效应因子的变化
The Changes of Th17 and Treg Cells in the Recurrent SpontaneousAbortion Patients
  
DOI:
中文关键词: 复发性自然流产  Th17 细胞  调节性T 细胞
英文关键词: Recurrent Spontaneous Abortion  Th17 Cell  Treg Cell
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Author NameAffiliation
ZHANG Xue-lian, RAO Li-juan, LI Ming-hua,YU Li-hui, WEI Xin 长沙市中心医院 
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中文摘要:
      目的:探讨复发性自然流产患者外周血中Th17、Treg细胞以及相关细胞因子的变化。方法:选择复发性自然流产患者25 例,正常妊娠妇女25 例以及正常非妊娠育龄妇女25 例,流式细胞术测定外周血中Th17 和Treg 细胞数量,ELISA 法测定血清 IL-10、TGF-茁及IL-17 的浓度。结果:复发性自然流产患者外周血中Th17 细胞百分率显著高于正常妊娠以及正常非孕妇女 (P<0.05),Treg 细胞百分率显著低于正常非孕妇女(P<0.05),但与正常妊娠妇女相比无显著性差异(P>0.05);复发性自然流产患者 外周血IL-10及TGF-茁水平显著低于正常妊娠妇女以及正常非孕妇女(P<0.05),而IL-17 水平显著高于正常妊娠妇女以及正常非 孕妇女(P<0.05)。结论:外周血Th17 细胞数和IL-17 水平的升高以及抑制性细胞因子IL-10 和TGF-beta水平的下降可能是复发性自 然流产发生的重要原因。
英文摘要:
      Objective:T he changes of Th17 cells, Treg cells and related cytokines in peripheral blood of recurrent spontaneous abortion (RSA) patients was discussed. Methods:25 recurrent spontaneous abortion patients, 25 normal pregnant women and 25 normal non-pregnant women at childbearing age were selected in this study. The numbers of Th17 and Treg cell in peripheral blood were measured by flow cytometry. The concentrations of serum IL-10, TGF- beta, and IL-17 were determined by ELISA kits. Results: The percentage of Th17 cell in peripheral blood of RSA patients was significantly higher than that of normal pregnant and normal non-pregnant women(P<0.05), the percentage of Treg cell in peripheral blood of RSA patients was significantly lower than that in normal non-pregnant women(P<0.05), but there was no significant difference in comparison with normal pregnanct women(P>0.05). The levels of serum IL-10 and TGF-茁of RSA patients were significantly lower than that of normal pregnant women and normal non-pregnant women(P<0.05), while IL-17 level was significantly higher than that in normal pregnant and non-pregnant women(P<0.05).Conclusion:The number of Th17 cell, IL-17 level and serum level of inhibitory cytokines IL-10 and TGF-beta may play an important role in the development of recurrent spontaneous abortion.
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