| 白录军 周天 冯旭阳 郑鹏飞 徐瑞芬.壳聚糖-有机累托石/海藻酸钠复合纳米粒的制备[J].现代生物医学进展英文版,2014,14(11):2029-2031. |
| 壳聚糖-有机累托石/海藻酸钠复合纳米粒的制备 |
| Preparation of Quaternized Chitosan (QC)/alginate (ALG) ComplexNanoparticles |
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| DOI： |
| 中文关键词: 壳聚糖 纳米粒 有机累托石 |
| 英文关键词: Quaternized chitosan Nanoparticles Organic Rectorite |
| 基金项目:国家自然科学基金项目（8100597；81070248） |
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| 中文摘要: |
| 目的：以BSA 作为模型药物，制备壳聚糖季铵盐-OREC 复合物纳米微粒，建立一种安全有效的药物控释传递系统。方法：超
声条件下，制备不同质量比的具有壳聚糖硅酸盐插层结构的复合物纳米微粒，观察其形态学特征、进行红外光谱分析。同时，测定
OREC 对BSA 包封率和载药量的影响。结果：成功制备了不同质量比的OREC-HTCC 纳米粒子。电镜结果显示纳米粒呈圆球形，
均匀，平均粒径约为30nm。红外图谱分析证实，HTCC插入了OREC 插层中，BSA成功地包裹入HTCC-ALG/OREC 混合材料制
备的纳米微粒。加入OREC 后，纳米粒子的包封率及载药量均明显提高，但随着加入量的增加，包封率及载药量逐渐减少。结论：
OREC-HTCC 纳米粒子是良好的蛋白药物载体，具有粒径小、包封率高、缓释效果好等优点，为CS-OREC 作为潜在的药物给药系
统的进一步应用提供科学依据。 |
| 英文摘要: |
| Objective:To preparation of quaternized chitosan (QC)/alginate (ALG) complex nanoparticles with BSA . Therefore,
it is necessary to establish an approach for fabricating an efficient controlled release drug delivery system. Methods:Under the condition
of ultrasonic, preparation of different mass ratio with silicate chitosan intercalated structure complex nanoparticles. Morphology, infrared
spectrum analysis, and the encapsulation efficiency and the loading capacity of nanoparticles were investigated. Results:OREC-HTCC
nanoparticles were prepared successfully and universally spherical with a diameter of approximately 30 nm. FT-IR results confirmed that
HTCC chains had intercalated into the interlayer of OREC and BSA was encapsulated by nanoparticles prepared by HTCC-ALG/OREC
mixed material. After introduction of OREC, encapsulation efficiency and drug load of nanoparticles were significantly enhanced. However,
encapsulation efficiency and drug load declined with the increase of OREC introduction. Conclusion:The nanoparticles prepared by
HTCC-OREC have been used as drug carrier for protein, have the advantages of small size, high encapsulation efficiency and slow release.
It provides scientific data for modulating the release of oral drug. It could be expected to be potential drug delivery system though
there were few related reports. |
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