| 杨杰1,2 单兆亮1,3△ 王玉堂1,3△ 郭红阳3 郭晓东1,4 林琨3 国建萍3
赵月香3 王海军3.心力衰竭合并房颤患者血浆脑钠肽水平及相关因素分析*[J].现代生物医学进展英文版,2014,14(10):1893-1895. |
| 心力衰竭合并房颤患者血浆脑钠肽水平及相关因素分析* |
| Analysis of the Relative Factors on BNP of Patients with the Combinationof Atrial Fibrillation and Heart Failure* |
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| DOI： |
| 中文关键词: 心力衰竭 脑钠肽 心房颤动 |
| 英文关键词: Heart failure Brain natriuretic peptide Atrial fibrillation |
| 基金项目:国家自然科学基金青年科学基金项目( 30901795） |
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| 中文摘要: |
| 摘要目的：探讨心力衰竭合并房颤患者血浆脑钠肽水平变化及相关因素，为心血管疾病的临床诊断提供理论依据。方法：选取我
院2011 年1 月-2013 年1 月收治的心力衰竭患者94 例，分为窦性心律组和心房颤动组。分别抽取两组患者的血液样本并检测血
浆中的BNP 浓度，比较不同NYHA分级患者血浆内的脑钠肽水平的变化情况，记录左心房和左心室舒张末内径及房颤持续时间
等。结果：心力衰竭合并心房颤动组与窦性心律组血浆BNP水平比较，心房颤动组高于窦性心律组；差异有统计学意义(P<0.05)；
两组NYHA不同分级相互比较，Ⅱ级、Ⅲ级和Ⅳ级间的BNP 水平，心房颤动组BNP 水平均高于窦性心律组；差异显著具有统计
学意义(P<0.05)；血浆BNP 水平与患者年龄、左心房大小、左心室大小、房颤持续时间因素呈正相关(r 分别为0. 0.801, 0.748, 0.854
和0.703, P<0. 05)，与左心室射血分数呈负相关(r=-0.41, P<0.05)。结论：BNP血浆浓度与心功能状态密切相关，BNP浓度的检测有
助于临床心血管疾病的诊断。 |
| 英文摘要: |
| ABSTRACT Objective:To explore the BNP levels of patients in atrial fibrillation combined with heart failure, and to analyze the
the correlative factors in order to provide some prospects to the clinical on cardiac diagnosis. Methods:94 patients with heart failure who
were treated in our hospital from January 2011 to 2013 were selected and divided into the sinus rhythm group and the atrial fibrillation
group on the basis of presence of atrial fibrillation. The blood samples of patients were taken and the plasma BNP level were detected.
Then the end-diastolic diameter of left atrium and ventricular, duration of atrial fibrillation were inspected and the BNP levels of different
NYHA classification were compared and analyzed. Results:There was statistically significant difference on the levels of plasma BNP
between the heart failure in sinus rhythm group and the atrial fibrillation group (P<0.05); At different NYHA grading, there were was
statistically significant difference about the BNP levels of Ⅱ, Ⅲ and Ⅳ(P<0.05); There was a positively relative factors to the BNP levels
such as the age of patients, the size of the left atrium and ventricular, the duration of atrial fibrillation, as well as the negatively relative
factors with the ejection fraction of the left ventricular. Conclusiong:The BNP level of atrial fibrillation in patients with heart failure was
higher and it is helpful to clinical diagnosis of cardiac disease by detecting the concentration of BNP. |
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