| 苏林娜刘向强吕丽芬聂勇战时永全△.FXR 在胃粘膜肠化生及胃癌中的表达及其意义研究*[J].现代生物医学进展英文版,2014,14(10):1875-1878. |
| FXR 在胃粘膜肠化生及胃癌中的表达及其意义研究* |
| The Study of Expression and Significance for FXR in the GastricMucosal Intestinal Metaplasia and Gastric Cancer* |
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| DOI： |
| 中文关键词: 肠化生 FXR 胃癌 |
| 英文关键词: Intestinal metaplasia Farnesoid X receptor(FXR) Gastric cancer. |
| 基金项目:国家自然科学基金项目(81270445；81370484) |
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| 中文摘要: |
| 摘要目的：研究FXR 在胃炎,胃粘膜肠化生及胃癌组织中的表达，分析其在胃癌发生中的意义。方法：采用免疫组化方法检测
FXR在55 例胃炎组织, 61 例胃黏膜肠化生组织及61 例胃癌组织中的表达，利用统计学方法SPSS17.0软件分析其在三种组织中
的表达变化，结合文献回顾，分析FXR在胃癌发生中的意义。结果：FXR 在胃黏膜肠化生中的表达明显高于胃炎组织(P<0.05)，而
在胃癌组织中，FXR 的表达显著低于胃粘膜肠化生组织(P<0.05)。结论：FXR 是一个潜在的胃癌发生生物标记物，其具体机制有待
于进一步探索。 |
| 英文摘要: |
| ABSTRACT Objective：To investigate the expression of FXR in gastritis tissues, gastric mucosal intestinal metaplasia tissues and
gastric cancer tissues, and analyze the significance of FXR in gastric carcinogenesis.Methods： Immunehistochemistry was performed to
detect the FXR expression in gastritis, intestinal metaplasia tissues, and gastric cancer tissues, and the expressional relation between these
three groups of tissue were analyzed by SPSS17.0. The significance of FXR in gastric cancer was also analyzed. Results：The expression
of FXR in gastric mucosal intestinal metaplasia tissues was significantly higher than that in gastritis tissues (P<0.05). However, in the
gastric cancer group, the FXR expression was clearly lower than that in gastric mucosal intestinal metaplasia tissues (P<0.05).
Conclusion：FXR is a potential gastric biomarker, and its machenisms were to be studied in future. |
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