| 马良 王忠慧 陈菲 汪亚宏 李珊珊.靶控输注静脉麻醉和腰硬联合麻醉对直肠癌根治术患者免疫功能的
影响研究[J].现代生物医学进展英文版,2014,14(9):1740-1743. |
| 靶控输注静脉麻醉和腰硬联合麻醉对直肠癌根治术患者免疫功能的
影响研究 |
| The Study of Target-Controlled Infusion Intravenous Anesthesia and EpiduralAnesthesia on Immune Function of the Patients with Colorectal CancerResection |
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| DOI： |
| 中文关键词: 靶控输注静脉麻醉 腰硬联合麻醉 直肠癌根治术 免疫功能 |
| 英文关键词: Target controlled infusion intravenous anesthesia Epidural anesthesia Colorectal cancer resection Immune function |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨靶控输注静脉麻醉和腰硬联合麻醉对直肠癌根治术患者免疫功能的影响。方法：选择在我院行直肠癌根治术的
72 例患者，将其分为观察组和对照组各36 例，其中观察组给予靶控输注静脉麻醉，对照组采用腰硬联合麻醉，对两组患者手术时
间、术中出血量以及免疫球蛋白水平（IgG、IgA、IgM）、血清白介素-6 水平（IL-6）、肿瘤坏死因子-a 水平（TNF-a）以及T 细胞亚群
（CD3、CD4）水平进行对比。结果：观察组手术平均时间为（130.5± 11.7）min，术中平均出血量为（271.3± 37.8）ml，与对照组比较差
异均无统计学意义（P>0.05）；两组IgG、IgA 及IgM，在T1、T2、T3 及T4 时刻水平比较差异均无统计学意义（P>0.05）；两组IL-6、
TNF-a、CD3 及CD4 在麻醉后较T1 时均有明显变化，比较差异均有统计学意义（P<0.05），且观察组变化较对照组更为明显，两组
比较差异有统计学意义（P<0.05）。结论：靶控输注静脉麻醉和腰硬联合麻醉对直肠癌根治术患者免疫功能均存在抑制作用，且以
抑制细胞免疫功能为主，而腰硬联合麻醉抑制作用较低，值得推广应用。 |
| 英文摘要: |
| Objective:To investigate the target-controlled infusion intravenous anesthesia and epidural anesthesia on immune
function of the patients with colorectal cancer resection.Methods:72 patients with colorectal cancer resection were divided into observation
group and control group, and 36 cases were in each group, the observation group was given target controlled infusion intravenous
anesthesia while the control group was received lumbar epidural anesthesia, the operative time, blood loss, and immunoglobulin levels
(IgG, IgA, IgM), serum levels of interleukin-6 (IL-6), tumor necrosis factor-a levels (TNF -a) and T-cell subsets (CD3, CD4) levels were
compared between the two groups.Results:The mean operative time of the observation group was (130.5± 11.7) min, mean intraoperative
blood loss was (271.3± 37.8) mL, and it showed no significant difference compared with the control group (P>0.05); the IgG, IgA
and IgMat T1, T2, T3 and T4 levels had no significant difference (P>0.05); IL-6, TNF-a, CD3 and CD4 after anesthesia changed significantly
compared with T1, the differences were statistically significant (P<0.05), and changes in the observation group was significant than
the control group, the difference was statistically significant (P<0.05).Conclusion:Target-controlled infusion intravenous anesthesia and
epidural anesthesia on immune function for patients with colorectal cancer resection are present inhibition, and it can suppress immune
function-based, and the inhibition of epidural anesthesia is low, which is should be widely applied in clinical. |
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