| 张金敏 王翔宇 李南 江金潇 王蓁.PB 方案在宫颈癌介入化疗中的疗效观察
及对Wee1 表达的影响[J].现代生物医学进展英文版,2014,14(9):1719-1723. |
| PB 方案在宫颈癌介入化疗中的疗效观察
及对Wee1 表达的影响 |
| Application Of Cisplatin Combined With Bleomycin In InterventionalChemotherapy For Cervical Cancer |
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| DOI： |
| 中文关键词: 顺铂 博莱霉素 介入化疗 宫颈癌 Wee1 蛋白 |
| 英文关键词: Cisplatin Bleomycin Interventional chemotherapy Cervical cancer Wee1 protein |
| 基金项目: |
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| 中文摘要: |
| 目的：研究PB 方案(顺铂DDP、博莱霉素BLM)，并了解其对Wee1 蛋白表达的影响。方法：1、用PB方案对64 例ⅠB～ⅡB
期宫颈癌病人进行介入化疗,观察化疗前后宫颈肿瘤体积变化及化疗后反应，评价介入化疗的效果。2、比较介入化疗后手术患者
（观察组）与直接手术患者（对照组）术中情况及术后病理情况,评价介入化疗的近期疗效。3、测定介入前后Wee1 表达的变化，及
与临床病理的关系，了解PB方案对Wee1 的影响。结果：PB 方案介入化疗的有效率(CR + PR)为87.5% ,缓解率为96.9%，34.4%
出现了发热反应，未见其他明显不良反应。试验组和对照组手术时间分别为（2.92 ± 0.3）h 和（3.28 ± 0.55）h，术中出血量分别为
（453.1 ± 131.9）mL和（542.8 ± 5.6）mL，两组在手术时间和术中出血量方面差异有统计学意义（P ＜0.05)，两组术后在盆腔淋巴结
转移、脉管浸润、宫旁浸润及阴道切缘受累方面差异均有统计学意义（P ＜ 0.05）。PB 方案介入化疗后，Wee1 的表达较介入化疗前
显著降低，差异有统计学意义（P＜0.05)，和临床分期、病理类型、淋巴结转移及病理分级无关，差异无统计学意义（P＞0.05)。结
论：PB介入化疗方案有效、低毒,对ⅠB～ⅡB期宫颈癌治疗具有较好的疗效，PB 方案是值得推广的介入化疗方案，Wee1 蛋白有
望成为监测PB 方案介入化疗疗效的指标。 |
| 英文摘要: |
| Objective:To investigate the interventional Chemotherapy of cisplatin combined with bleomycin (PB) in Carcinoma
of Uterine Cervix, and to study the effect of the expression of Wee1 protein.Methods:1:64 patients with carcinoma of the uterine cervix,
stageⅠ B～ⅡB, were treated with interventional Chemotherapy of PB, and response and toxicity were observed to evaluate the effect
and security of PB. 2: Compared intraoperative situation and Postoperative pathological condition in patients who received radical
hysterectomy directly.3: Detected the Wee1 expression changes before and after intervention to investigate the effect of Wee1 PB
scheme and the clinical pathology. Results:The efficient (CR + PR) of PB scheme intervention chemotherapy was 87.5%, alleviate rate
was 96.9%, heating reaction 34.4%, and there was no the other obvious adverse reaction. The surgical operation time of the treatment
group and control group was (2.92± 0.3) h and (3.28 ± 0.55) h respectively, and intraoperative amount of bleeding was (453.1± 131.9)
ml and (542.8± 75.6) mL. The operation time and intraoperative amount of bleeding of the two groups were statistically significant
differences (P< 0.05). The differences in the fields of metastasis of pelvic lymph node, vascular infiltration, infiltration of palace side and
vaginal cutting edge involvement were statistically significant (P< 0.05). After the PB scheme intervention chemotherapy, the expression
of Wee1 was significantly lower than before (P<0.05), and it had nothing to do with the clinical stage, pathological type, lymph node
metastasis and pathology classification, and the difference was not statistically significant (P>0.05).Conclusion:PB scheme is an
effective, low poison scheme, also it has good curative effect for Ⅰ B ~ Ⅱ B stage cervical cancer, it is worth to be popularized, Wee1
protein is expected to become the monitoring curative effect index for the PB scheme. |
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