| 侯江红1 张龙龙2 李军农1 王宇晖1 郑燕1.脑心通胶囊辅助治疗不稳定型心绞痛的临床疗效和安全性的Meta 分析[J].现代生物医学进展英文版,2014,14(8):1545-1549. |
| 脑心通胶囊辅助治疗不稳定型心绞痛的临床疗效和安全性的Meta 分析 |
| The Clinical Curative Effect and Safety of Naoxintong Capsules in theTreatment of Unstable Angina: A Meta-analysis |
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| DOI： |
| 中文关键词: 脑心通胶囊 不稳定型心绞痛 临床疗效 安全性 Meta 分析 |
| 英文关键词: Naoxintong Capsules Unstable angina Clinical efficacy Safety Meta-analysis |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：系统评价脑心通胶囊辅助治疗不稳定型心绞痛的临床疗效及其安全性。方法：计算机检索PubMed(1966～2012.3)、
EMbase(1974～2012.3)、Cochrane Library(2012 年第3 期)、CBM(1978～2012.3)、CNKI(1994～2012.3)、VIP(1989～2012.3)。纳入脑
心通胶囊联合常规药物治疗不稳定型心绞痛的随机对照试验(RCT)，并补充检索纳入研究的参考文献；按Cochrane 系统评价方法
对纳入研究进行资料提取及质量评估后，采用RevMan 5.1 软件进行统计学分析。结果：共纳入11 个RCT，包括共1384 例患者，
Meta 分析结果显示：与常规药物治疗相比，脑心通胶囊联合常规药物明显缓解不稳定型心绞痛患者的临床症状，差异有统计学意
义[RR=1.24，95%CI(1.18-1.31)，P<0.01]，提高了心电图的改善率[RR=1.35，95%CI(1.24-1.47)，P<0.01]。结论：目前研究表明脑心通
胶囊辅助治疗不稳定型心绞痛的短期疗效明显优于常规治疗，但其不良反应和远期疗效尚不确定，需要更多高质量随机对照试
验进一步证实。 |
| 英文摘要: |
| ABSTRACT Objective:To review the clinical curative effect and safety of Naoxintong Capsules in the treatment of patients with
Unstable Angina. Methods:PubMed(1966-2012.3), EMbase (1974-2012.3), Cochrane Library(Issue3,2012), CBM(1978-2012.3), CNKI
(1994-2012.3), VIP (1989-2012.3) were electronically searched. Randomized controlled trials (RCTs) about Naoxintong Capsules plus
conventional drugs in the treatment of Unstable Angina were included, and the relevant references of the included papers were also
manually searched. Study selection and analysis were undertaken according to the Cochrane Handbook, and RevMan 5.1 was applied for
statistical analyses.Results: Eleven RCTs involving 1384 patients with Unstable Angina were included. The results of meta-analysis
showed that the improvement of symptoms [RR=1.24, 95%CI (1.18-1.31),P<0.01], the improve of ECG [RR=1.35, 95%CI(1.24-1.47),
P<0.01] were superior in the combination arm to the conventional drugs alone arm. Conclusion:The current evidence available showed
that the combination of Naoxintong Capsules and conventional drugs may significantly improve the short-term efficacy comparing with
conventional drugs alone. However, long-term efficacy and adverse events were not clear yet; more high-quality RCTs should be
conducted. |
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