| 谭建荣1 罗显克1 王大东1 黄宗林1 黄滟添1 谢伟2.肝硬化患者血清胆碱酯酶和腺苷脱氨酶联合检测的临床意义*[J].现代生物医学进展英文版,2014,14(8):1494-1496. |
| 肝硬化患者血清胆碱酯酶和腺苷脱氨酶联合检测的临床意义* |
| The Clinical Significance of Cirrhosis Combined Detection SerumCholinesterase and Adenosine Deaminase* |
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| DOI： |
| 中文关键词: 胆碱酯酶 腺苷脱氨酶 肝硬化 临床分型 |
| 英文关键词: Cholinesterase Adenosine deaminase Cirrhosis Clinical type |
| 基金项目:国家自然科学基金项目（81170397） |
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| 中文摘要: |
| 摘要目的：探讨血清胆碱酯酶和腺苷脱氨酶联合检测在诊断肝硬化不同病程分期的临床意义。方法：选择20 例失代偿期肝硬化
患者分为失代偿组，随机选取20 例代偿期肝硬化患者和20 例健康人群分别分为代偿组和健康组，对3 组人群的血清胆碱酯酶
和腺苷脱氨酶活性进行检测并比较其差异。结果：代偿组和失代偿组的CHE 活性均要显著低于健康组，差异有统计学意义（t=8.
34，P<0.01、t=12.03，P<0.01），失代偿组要显著低于代偿组，差异有统计学意义（t=4.07，P<0.01）；代偿组和失代偿组ADA活性均要
显著高于健康组，差异有统计学意义（t=11.19，P<0.01、t=17.07，P<0.01），失代偿组要显著高于代偿组，差异有统计学意义（t=7.38，
P<0.01）。结论：血清胆碱酯酶和腺苷脱氨酶活性随着肝硬化病程发展发生显著变化，其联合检测可以为病程发展的临床诊断提供
一定的依据。 |
| 英文摘要: |
| ABSTRACT Objective：To investigate the clinical significance in diagnosing different stages of cirrhosis by combining detection
serum cholinesterase and adenosine deaminase. Methods：20 cases of patients with decompensated cirrhosis were divided into
decompensation group, randomly selected 20 cases of compensated cirrhosis patients and 20 healthy subjects were divided into
compensatory group and healthy group, detected 3 groups serum cholinesterase, serum adenosine deaminase activity and compared the
differences. Results：Compensation group and decompensated group CHE activity were to be significantly lower than the healthy group,
decompensated group was significantly lower than the compensatory group, compensation group and decompensated group ADA activity
were to be significantly higher than the healthy group, decompensated group was significantly higher than compensatory group.
Conclusion：Serum cholinesterase and adenosine deaminase activity with the progression of cirrhosis significant change, the combined
detection could be provide a basis for progression of clinical diagnosis. |
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