| 高峰1,3 肖暖2 李平3 王绿娅4 柳克晔2△.急性心肌梗死患者冠脉搭桥术前中性粒细胞-淋巴细胞比率与
围术期心肌损伤相关分析*[J].现代生物医学进展英文版,2014,14(8):1475-1478. |
| 急性心肌梗死患者冠脉搭桥术前中性粒细胞-淋巴细胞比率与
围术期心肌损伤相关分析* |
| Correlation of Preoperative Neutrophil to Lymphocyte Ratio withPerioperative Myocardial Injury after Coronary Artery Bypass Surgery inPatients with AMI* |
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| DOI： |
| 中文关键词: 冠脉搭桥术 围术期心肌损伤 中性细胞- 淋巴细胞比率 肌钙蛋白 |
| 英文关键词: Coronary artery bypass surgery Perioperative myocardial injury Neutrophil to lymphocyte ratio Cardiac troponint I |
| 基金项目:国家自然科学基金项目（81271923；81000090） |
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| 中文摘要: |
| 摘要目的：探讨急性心肌梗死患者冠脉搭桥（CABG）术前中性粒细胞- 淋巴细胞比率（NLR）与围术期心肌损伤的关系，为临床
CABG 围术期心肌保护提供参考依据。方法：选取2012 年1 月至2012年6 月于首都医科大学附属北京安贞医院因急性心肌梗死
接受冠脉搭桥手术（CABG）患者210 例，收集术前血常规及术后肌钙蛋白I（cTnI）及肌酸激酶同工酶（CK-MB），计算NLR；采用
四分位法根据NLR 水平将患者分为四组，比较各组cTnI 及CK-MB 峰值，多元逐步回归分析NLR 与cTnI 及CK-MB 峰值的相
关性。结果：随着NLR 水平升高，高血压病史和射血分数＜50%患者比例逐渐增多；白细胞计数、术后CK-MB 及cTnI峰值、术后
血肌酐值均逐渐增加；多元逐步回归分析显示，NLR、WBC分别与cTnI 峰值呈正相关（r=0.526，r=0.186，P<0.05）。结论：术前
NLR、WBC 与cTnI 峰值呈正相关，NLR 可能是反应急性心肌梗死患者冠脉搭桥围术期心肌损伤的良好标志物。 |
| 英文摘要: |
| ABSTRACT Objective:To study the correlation of preoperative neutrophil to lymphocyte ratio(NLR) withperioperative myocardial
injury after coronary artery bypass surgery (CABG) in patients with AMIat admission. Methods:Two hundred and ten CABG patients
with AMI, admitted to Beijing Anzhen Hospital from January 2012 to June 2012.Preoperative white blood cells count (WBC), neutrophil
count (NC), lymphocyte count (LC), postoperative troponin I (cTnI) and creatine kinase isoenzyme (CK - MB ) were measured at
admission and NLR were calculated. Patients were divided into four groups according to NLR. Difference in their peak cTnI and CK-MB
values were compared and correlation of NLR with peak cTnI and CK-MB values was analyzed. Results:With the increment of NLR, the
proportions with hypertension history or ejection fraction ＜50%, WBC, peak cTnI and CK-MB values were significantly higher[A1].
Multiple stepwise regression analysis showed that the WBC and NLR were positively correlated with the peak cTnI value（r=0.526，r=0.
186, P＜0.05）. Conclusion:The WBC count and NLR are positively correlated with the peak cTnI values after coronary artery bypass
surgery in patients with AMI at admission in a significant linear manner, indicating that NLR is a good indication for perioperative
myocardial injury after coronary artery bypass surgery in patients with AMI |
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