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目的：观察封闭式负压引流技术(VSD)联合金因肽治疗手足外科难愈性伤口的临床疗效，为临床联合运用提供依据。方法： 86 例手足外科难愈性伤口患者随机分为治疗组和对照组各43 例，治疗组采用VSD联合金因肽治疗，对照组采用常规换药治疗，观察两组临床疗效和上皮化时间、愈合时间、创面愈合率、换药次数、伤口疼痛评分、住院费用差异。结果：治疗组总有效率 90.70%；对照组总有效率72.09%；两组比较，有显著性差异(P＜0.05)；治疗组上皮化时间、愈合时间、创面愈合率、换药次数、伤口疼痛评分、住院费用较对照组相比明显缩短，差异有统计学意义(P<0.05)。结论：VSD 联合金因肽治疗手足外科难愈性伤口疗效确切，能更好促进损伤组织的修复，加速创面愈合，值得临床推广应用。

英文摘要:

Objective:To study the clinical research of Vacuum Sealing Drainage combinated with rhEGF on treating refractory wounds of the hand and foot surgery, to provide basis for clinical joint use.Methods:86 patients were randomly divided into treatment group 43 cases and 43 cases of control group, the treatment group were treated by VSD combined with rhEGF,while the control group were treated with conventional dressing, the efficacy and the difference of epithelialization time, healing time, wound healing rate, number of switches, wound pain score, hospitalization expenses of two groups were observed.Results:The total effective rate of the treatment group was 90.70%, the control group was 72.09%, the two groups in clinical curative effect had significant difference (P<0.05) ;the epithelialization time, healing time, wound healing rate, number of switches, wound pain score, hospitalization expenses were reduced in treatment group than those in the control group(P＜0.05).Conclusion:VSD combined rhEGF had definite effect for refractory wounds of the foot surgery,which could better promote tissue damage repair, accelerating wound healing, it is worthy of clinical application.

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