| 林祖岩 董白晶 赵天书 康现鑫 李庆腊 刘晓谦
△.脑胶质瘤神经干细胞治疗研究进展[J].现代生物医学进展英文版,2014,14(6):1191-1193. |
| 脑胶质瘤神经干细胞治疗研究进展 |
| Recent Advance of Neural Stem Cells for Treating Glioma |
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| DOI： |
| 中文关键词: 神经干细胞 胶质瘤 治疗 |
| 英文关键词: Neural stem cells Glioma Therapy |
| 基金项目: |
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| 中文摘要: |
| 摘要： 脑胶质瘤是神经外科最常见的恶性肿瘤, 发病率约占全身肿瘤的 5％ ,占儿童肿瘤的 70％ ， 且呈逐年上升的趋势。脑胶质瘤
恶性程度高，生长迅速， ５ 年生存率很低， 其中高级别胶质瘤具有极强的侵袭能力， 目前尚缺乏很有效的根治方法。 手术切除肿瘤
的难度很大， 术后极易复发， 预后比较差，对人类健康乃至生命的危害极大。随着分子生物学的发展以及相关生物技术的应用,从
基因水平揭示脑胶质瘤的发生发展机制， 并寻求有效的基因治疗方法成为人类研究肿瘤治疗新的研究方向。 Reynolds 和 Richards
等先后从成年小鼠的纹状体中分离出能够不断增殖且具有多向分化潜能的细胞群， 并提出了神经干细胞（ neural stem cell, NSC ）
的概念。 NSC 具有高度增殖和自我更新的能力， 且有迁移功能以及与正常脑组织良好融合的特性， 这为基因治疗胶质瘤提供了良
好的基础。 |
| 英文摘要: |
| ABSTRACT:Glioma is the most common malignant tumor of neurosurgery, which morbidity accounting for 5% of systemic cancer,
accounting for 70% of the tumors of children, and showed an increasing trend. High degree of malignant glioma grows rapidly, which has
a very strong invasion of glioma.The 5-year survival rate is very low, because it is lack of effective cure. It is very difficult to deal the
tumor with surgical resection and very vulnerable to relapse after a relatively poor prognosis, which have done great harm to human
health and even life. With the development of molecular biology and biotechnology applications, it has become a new research direction
of human cancer treatment to reveal the occurrence of glioma development mechanism and seek effective methods for gene therapy at the
gene level. Reynolds and Richards have isolated cell populations from adult mouse striatum which can keep proliferating possessed with
multiple differentiation potential and put forward concept of neural stem cells (neural stem cell, NSC). NSC have highly proliferation and
self-renewal capacity and migration functions as well as the characteristics of a good fusion with normal brain tissue, which providesa
good foundation for gene therapy for glioma. |
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