| 马东东
1,2
周玉杰
1,2
路婷婷
3
卢 涛
2.组织工程皮肤研究现状[J].现代生物医学进展英文版,2014,14(6):1183-1187. |
| 组织工程皮肤研究现状 |
| Research of Skin Tissue Engineering* |
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| DOI： |
| 中文关键词: 组织工程皮肤 支架材料 种子细胞 |
| 英文关键词: Skin tissue engineering Scaffold materials Seed cells |
| 基金项目:国家自然科学基金项目（ 81072964 ） |
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| 中文摘要: |
| 摘要： 组织工程皮肤是通过培养功能细胞， 将其与细胞外基质及支架材料互相作用， 制成的具有生物活性的人工皮肤替代物。组
织工程皮肤的发展为修复皮肤创面，重建皮肤功能， 治疗皮肤病提供了新的方法。本文从皮肤种子细胞培养、 真皮支架材料和体
外构建活性复合皮三个方面对组织工程皮肤的研究进展进行了综述。目前组织工程皮肤在一定程度上克服了原有的皮肤供区不
足、 免疫排斥、 传播疾病等各种问题。新的种子细胞和支架材料逐渐成熟， 并逐渐应用于临床治疗； 在种子细胞和真皮替代物基础
上发展起来的复合皮肤可以更快速的促进缺损皮肤的愈合， 但与在体皮肤比较尚有差距。组织工程皮肤是理想的皮肤替代物， 具
有良好的发展前景， 未来的研究应该着眼于模仿机体皮肤的生理结构和功能， 使愈合后的皮肤与在体皮肤融为一体。 |
| 英文摘要: |
| ABSTRACT：Skin tissue engineering are artificial skin substitutes.It is made of culturing functional cells, and is used for interacting
with the extracellular matrix and scaffold materials. The development of skin tissue engineering provides new methods for skin wounds
repair, rebuild the skin functions, and the treatment of skin diseases. The review summarizes culture of skin cell, dermal scaffold material
and constructed activity composite in vitroskin . Skin tissue engineering solve the problems toa certain extent like the lack of original
skin, immune rejection and spread diseases. The new seed cells and scaffold materials are being to mature and applied to the clinical
treatment gradually. The development of seed cells and dermal substitutes based on composite skin can promote faster healing of the
defects of the skin, but there are still some gaps compared with the body skin. Skin tissue engineering is an ideal skin substitute, which
has prospects for development. The future research should focus on mimic the structure and function of the physiology of the body skin,
and blend it in vitro skin. |
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