| 黄 平
1
陈 玖
2△
唐 英
1
杨来启
2
李亚萍
2.产后抑郁症患者听感觉门控 P50 的研究[J].现代生物医学进展英文版,2014,14(6):1152-1154. |
| 产后抑郁症患者听感觉门控 P50 的研究 |
| Research on the P50 Auditory Sensory Gating Potential in Patients withPostpartum Depression* |
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| DOI： |
| 中文关键词: 产后抑郁症 感觉门控 P50 听感觉门控 |
| 英文关键词: Postpartum depression (PPD) P50 auditory sensory gating potential Anditory sensory gating |
| 基金项目:军队中医药科研专项课题 （10ZYX108 ） |
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| 中文摘要: |
| 摘要 目的： 探讨产后抑郁症患者感觉门控 P50 的变化特征，为产后抑郁患者的早期预防提供参考依据。方法： 采用配对听觉条件
(S1)、测试(S2)刺激范式， 对本院 2011 年 1 月至 2012 年 6 月收治的 26 例产后抑郁症患者(实验组)进行听觉诱发电位 P50 检测，
测量 P50 的潜伏期、 波幅， 并与 25 例健康被试者(对照组)的结果进行比较。 结果： (1) 与对照组相比， 实验组 S1-P50 潜伏期[(56.62
± 17.42) ms vs. (49.86 ± 15.21) ms]， S2-P50 潜伏期[(57.36 ± 15.42) ms vs. (50.04 ± 16.27) ms]的差异均无统计学意义(P>0.05)； (2)
与对照组相比， 实验组 S1-P50 波幅[(3.58 ± 1.72) μV vs. (1.13 ± 0.91) μV]显著降低， 差异有统计学意义(P<0.05)； S2-P50 波幅[
(1.32 ± 1.16) μV vs. (1.48 ± 1.05) μV]差异无统计学意义(P>0.05)； (3) 与对照组相比， 实验组 S2/S1 波幅比值[(1.17 ± 0.26) vs.
(0.41 ± 0.13)]显著升高， 差异有统计学意义(P<0.05)。结论： 产后抑郁症患者感觉门控抑制能力有缺陷， P50 受损指标可能为评估
产后抑郁症患者的潜在生物学指标。 |
| 英文摘要: |
| ABSTRACT Objective：To explore the change characteristics of P50 auditory sensory gating potential in patients with postpartum
depression and provide references for the prevention of postpartum depression in early phase. Methods:26 cases of postpartum depression and 25 cases of healthy subjects were selected, the incubation period and amplitude of P50 was measured by paired clicks auditory
condition/testing stimulating paradigm.Results: (1) There was no significant difference for S1-P50 latencies [(56.62 ± 17.42) ms vs.
(49.86 ± 15.21) ms] and S2-P50 latencies [(57.36 ± 15.42) ms vs. (50.04 ± 16.27) ms] between the experimental group and the control
group (p>0.05). (2) Compared with the control group, the amplitude of S1-P50 was significantly lower [(3.58 ± 1.72)μ V vs. (1.13 ±
0.91) μV, P<0.05], and no significant difference of the amplitude of S2-P50 was [(1.32 ± 1.16) μV vs. (1.48 ± 1.05) μV, P >0.05] found
between two groups. (3) Compared with the control group, the amplitude ratio of S2/S1 was significantly higher [(1.17 ± 0.26) vs. (0.41
± 0.13), P<0.05] in the experimental group. Conclusion:Postpartum depression presented defect on the inhibiting ability of auditory sensory gating potential in a certain extent. P50 damaged indicator may bea potential biological marker for the evaluation of postpartum depression. |
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