| 李沛颖
1
宗志锋
2
董丽洁
1
韩俊丽
1
王 毅
3
陈协群
4△.参麦注射液对于白血病骨髓抑制期的治疗作用[J].现代生物医学进展英文版,2014,14(6):1144-1147. |
| 参麦注射液对于白血病骨髓抑制期的治疗作用 |
| Clinical Effect of Shenmai on the Treatment of Myeloid Leukemia with BoneMarrow Inhibition* |
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| DOI： |
| 中文关键词: 参麦注射液 白血病 骨髓抑制 治疗作用 |
| 英文关键词: Shenmai Myeloid leukemia Bone marrow inhibition Therapy effect |
| 基金项目:国家自然科学基金项目 （30871089 ） |
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| 中文摘要: |
| 摘要 目的： 探讨参麦注射液对于白血病骨髓抑制期的治疗作用。方法： 选取我院 2011 年 1 月至 2012 年 12 月收治的白血病的患
者 47 例， 随机分为两组， 观察组 24 例化疗的同时给予参麦注射液， 观察组患者 23 例只给予化疗， 比较两组患者化疗后的骨髓抑
制情况和感染发生情况。结果： 两组患者化疗效果显示总有效率分别为 66.7%和 65.2%， 无显著差别(P>0.05)。两组患者化疗骨髓
抑制后 WBC, Hb, PLT 的恢复时间分别为(6.32 ± 2.75) 天， (9.32 ± 2.12) 天和(7.31 ± 3.21) 天， 明显低于对照组(11.34 ± 4.34) 天，
(12.54± 3.21)天和(12.41± 4.32)天， 差异显著有统计学意义 （P<0.05 ） ； 观察组患者中性粒细胞 ANC<0.5× 10
9
/L 持续的时间明显少
于对照组， 差异明显有统计学意义 （ P<0.05 ） ； 观察组患者发生感染的比例明显低于对照组， 差异显著有统计学意义 （P<0.05 ）。结
论： 参麦注射液可以明显减轻白血病化疗后的骨髓抑制现象， 有效保护骨髓的造血功能， 缩短骨髓受抑制时间， 和降低感染率， 明
显提高患者生活质量。 |
| 英文摘要: |
| ABSTRACT Objective：To study the clinical effect of Shenmai on the myeloid leukemia with bone marrow inhibition.Methods: 47
cases of leukemia who were treated in our hospital from January 2011 to December 2012 were selected and randomly divided into two
groups, namely, the observation group (24 cases) and the control group (23 cases). Patients in the observation group were given
chemotherapy combined with Shenmai while patients in the control group were given chemotherapy. Then the suppression of bone marrow were compared between two groups after chemotherapy. Results:The efficacy rate of the observation group was 66.7%, the efficacy
rate of the control group was 65.2%, and there was no statistically significant difference between two groups (P>0.05). The duration of
the myeloid suppression period (WBC, Hb, PLT lower than normal level) (6.32± 2.75), (9.32± 2.12) and (7.31± 3.21d) in the observation group which were shorter than those of the control group (11. 34± 4. 34), (12.54± 3.21) and (12.41± 4.32d), and there was statistically
significant difference between two groups (P<0.05); the period of neutrophils ANC < 0.5 × 10
9
/L in the observation group was less than
that of the control group, and there was statistically significant difference between two groups (P<0.05); the infectious rate of the observation group was lower than that of the control group, and there was statistically significant difference between two groups (P<0.05).
Conclusion:Shenmai injection can significantly reduce the leukemia bone marrow suppression after chemotherapy, effectively protect the
bone marrow hematopoietic function, shorten the time of bone marrow suppression, and reduce the infection rate, improve patient quality
of life. |
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