| 俞建臣
1
赵亚群
1
王 永
1
赵贵亮
1
高冬晓
1
郑险峰.巨大垂体腺瘤经蝶手术后发生脑脊液鼻漏的危险因素分析[J].现代生物医学进展英文版,2014,14(6):1128-1130. |
| 巨大垂体腺瘤经蝶手术后发生脑脊液鼻漏的危险因素分析 |
| Analysis of Risk Factors on Cerebrospinal Fluid Rhinorrhea after theTreatment of Giant Pituitary Adenomas by Transsphenoidal Surgery* |
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| DOI： |
| 中文关键词: 巨大垂体腺瘤 经蝶手术 脑脊液鼻漏 发病原因 |
| 英文关键词: Giant pituitary adenomas Transsphenoidal surgery Cerebrospinal fluid rhinorrhea Etiology |
| 基金项目:国家自然科学基金项目 （81101616 ） |
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| 中文摘要: |
| 摘要 目的： 探讨巨大垂体腺瘤经蝶手术脑脊液鼻漏的发病原因， 并提出相关的修补措施。 方法： 选择 2009 年 2 月 -2012 年 8 月在
我院进行诊治的巨大垂体腺瘤患者 180 例， 所有患者均采用经蝶手术摘除巨大垂体腺瘤。观察预后情况。结果： 在接受经蝶手术
的 180 例患者中， 25 例发生脑脊液鼻漏， 发生率为 13.8%。其中男性 15 例， 女性 10 例。单因素多因素分析都显示肿瘤大小、 慢性
蝶窦炎与再次手术与脑脊液鼻漏的发生有直接关系，为独立的影响因素(P<0.05)。对 25 例出现脑脊液鼻漏的患者采用鼻内镜手
术进行治疗，全部病例经手术修复后获得一次性治愈。随访 6 个月， 无 1 例复发， 无术后并发症。结论： 巨大垂体腺瘤经蝶手术脑
脊液鼻漏的发病率比较高， 肿瘤大小、 慢性蝶窦炎与再次手术为主要的独立危险因素，要积极采用鼻内镜下治疗。 |
| 英文摘要: |
| ABSTRACT Objective：To analyze the risk factors on the cerebrospinal fluid rhinorrhea after the treatment of giant pituitary adenomas by transsphenoidal surgery, and to put forward the relevant remedial measures for clinical. Methods:180 patients with giant pituitary
adenomas who were diagnosed and treated by transsphenoidal surgery in our hospital from February 2009 to August 2012 were selected,
and the prognosis of patients were observed and analyzed.Results: CSF fistula occurred in 25 cases, the rate was 13.8%, including 15
males and 10 females. Univariate Multivariate analysis showed that the tumor size, chronic sphenoid sinusitis and reoperation occurred
with cerebrospinal fluid rhinorrhea which was directly related to the impact of independent factors (P<0.05). The patients with CSF fistulas were treated by endoscopic surgery. And all the patients got recovery after the surgery. After six-month's follow-up, there was no recurrence or postoperative complications.Conclusion: Giant pituitary adenomas by transsphenoidal surgery cerebrospinal fluid rhinorrhea
had relatively high incidence, tumor size, chronic sphenoid sinusitis with reoperation asa major independent risk factor, which should actively adopt endoscopic treatment. |
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