| 张洪亮王文波△ 李明宇李进取史雪峰.致炎细胞因子在骨性关节炎病理生理中的作用[J].现代生物医学进展英文版,2014,14(5):989-992. |
| 致炎细胞因子在骨性关节炎病理生理中的作用 |
| Role of Proinflammatory Cytokines in the Pathophysiologyof Osteoarthritis |
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| DOI： |
| 中文关键词: 骨性关节炎 细胞因子 白介素 肿瘤坏死因子 抗致炎细胞因子 |
| 英文关键词: Osteoarthritis Cytokines IL TNF Anti-proinflammatory cytokines |
| 基金项目: |
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| 中文摘要: |
| 摘要：骨性关节炎（OA）是一种退行性病变，表现为关节软骨破坏，关节边缘骨赘形成，并伴有不同程度滑膜炎症，其病因学和发病
机制还不是十分清楚。研究表明致炎细胞因子在骨性关节炎病发病的病理生理过程中起着重要的作用。本综述讨论目前关于致
炎细胞因子在OA 病理生理中的作用机制以及抗致炎细胞因子在治疗OA 中的新进展。 |
| 英文摘要: |
| ABSTRACT:Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling and inflammation of the
synovial membrane. However, this debilitating disease are poorly understood. Secreted inflammatory molecules, such as proinflammatory
cytokines, are among the critical mediators of the disturbed processes implicated in OA pathophysiology. This Review discusses the
current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA and addresses the potential of
anti-cytokine therapy in the treatment of this disease. |
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