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摘要：下肢动脉粥样硬化是2 型糖尿病(T2DM )患者最常见的大血管并发症之一。作为T2DM患者严重的慢并发症之一，下肢动脉粥样硬化可引起糖尿病足的发生，严重情况下可导致足坏疽。因此，阐明T2DM合并下肢动脉粥样硬化的危险因素，早期预防和治疗糖尿病合并下肢动脉粥样硬化症，不仅提高了患者的生活质量，而且减轻了家庭和社会的经济负担，具有较大的现实意义。影响T2DM患者下肢动脉粥样硬化的因素错综复杂，分为不可调控的和可调控的因素，不可调控的危险因素包括年龄、种族、遗传等，可调控的危险因素包括吸烟、高血糖、高血脂、高血压，以及近年提出的肥胖、胰岛素抵抗、高纤维蛋白血症、炎症等。本文就T2DM 合并下肢动脉粥样硬化的危险因素做一综述。

英文摘要:

ABSTRACT:Lower extremity atherosclerotic is one of the most common macrovascular complications of type 2 diabetes mellitus (T2DM). As one of the serious slow complications of T2DM, lower extremity atherosclerosis can lead to the occurrence of diabetic foot, in severe cases, lead to gangrene. Thus, to clarify the risk factors of T2DM with lower extremity atherosclerosis, early prevention and treatment of T2DM with lower extremity atherosclerosis, not only improve the patients, quality of life, but also reduce the economic burden of the family and society, has greater practical significance. The factors affecting T2DM patients with lower extremity atherosclerosis are complex, divided into non-regulated and regulated factors, non-regulated risk factors including age, race, genetic, regulated risk factors including smoking, high blood sugar, high cholesterol, high blood pressure , as well as have been proposed in recent years obesity, insulin resistance, high-fiber albumin, inflammation, etc. This article is to review the risk factors of T2DM with lower extremity atherosclerosis.

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