| 杨益鹏1 刘洋2 卢均坤1 张磊艺1 纪东华3 魏晓东1 杨军1△.2 型糖尿病患者血浆chemerin 水平与其冠脉病变程度
的相关性分析[J].现代生物医学进展英文版,2014,14(5):927-929. |
| 2 型糖尿病患者血浆chemerin 水平与其冠脉病变程度
的相关性分析 |
| Research on the Correlation of Plasma Chemerin Level with the Severityof Coronary Artery Lesions in type 2 Diabetes Mellitus |
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| DOI： |
| 中文关键词: 2 型糖尿病 冠状动脉病变 趋化素 |
| 英文关键词: Type 2 diabetes mellitus Coronary artery lesions Chemerin |
| 基金项目:黑龙江省卫生厅科研项目（2010510） |
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| 中文摘要: |
| 摘要目的：探讨2 型糖尿病患者血浆趋化素（chemerin）水平与冠脉病变程度的关系。方法：选取2011 年1 月～2012 年2 月我院
收治的2 型糖尿病（T2DM）患者92 例，均行冠状动脉造影检查。按冠状动脉造影结果分为单纯2 型糖尿病无冠状动脉病变组26
例（DM0）；合并单支冠状动脉病变组32 例（DM1）；合并双支以上病变组34 例（DM2）。另选取正常健康行冠脉造影检查者25 例
作为正常对照组（NC）。采用酶联免疫吸附法检测各组入选者血浆chemerin 水平，并分析其与冠脉病变程度的相关性。结果：
T2DM及T2DM 合并冠状动脉病变患者血浆chemerin 水平与NC组对比均明显升高，并且与冠状动脉病变严重程度呈正相关
（P<0.05）。各组血浆Chemerin 水平与BMI、HOMA-IR、TC、和APOB各指标间呈显著正相关(r分别为0.781、0.723、0.415、0.694，P
均＜0.01)。结论：2 型糖尿病患者冠状动脉病变的发生发展可能与血浆chemerin 升高有关。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the relationship between plasma chemerin level changes and coronary artery lesions in
patients with type 2 diabetes. Methods:82 patients with Type 2 diabetes mellitus (T2DM) were enrolled for the study and underwent
coronary angiography. The patients were further grouped according to the results of coronary angiography into 3 groups. 26 patients with
simple Type 2 Diabetes without coronary artery lesions were grouped DM0; 32 cases with only a single coronary artery disease were
grouped DM1; 34 cases with multiple coronary artery disease (2 or more vessels involved) were grouped DM2. 25 normal healthy
patients who underwent coronary angiography were selected as normal control group (NC). ELISA method was used measure plasma
chemerin levels. The plasma chemerin levels were compared with the body mass index (BMI), indicators of insulin resistance index
(HOMA-IR), total cholesterol (CHOL), apolipoprotein B（APOB）was done. Results:Compared to the normal control group, plasma
chemerin levels in the T2DM and T2DM subgroup of multiple coronary artery disease patients was significantly increased and it
positively correlated with the degree of coronary artery lesion (P<0.05). The plasma chemerin levels also positively correlated with
apolipoprotein B, HOMA-IR, CHOL and BMI (P<0.01).Conclusion: The development of coronary artery lesions in patients with Type 2
Diabetes may be associated with elevated levels of plasma chemerin. |
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