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摘要目的：探讨电针腧穴联合当飞利肝宁治疗非酒精性脂肪性肝炎(nonalcohlic steatohepatitis，NASH)的临床疗效及其安全性。方法：选择符合2010 年非酒精性脂肪性肝病诊疗指南[1]诊断标准的80 例非酒精性脂肪性肝炎患者，随机分为联合组（电针联合当飞利肝宁治疗组）和对照组（护肝宁治疗组）各40 例，两组患者均在纠正不良生活方式、控制饮食(BMI<24)、适量有氧运动等的基础上给予相应的治疗，对照组仅服用护肝宁，3 次/d，联合组服用当飞利肝宁及电针腧穴治疗。观察和比较两组的疗效、血清转氨酶、血脂水平、脂肪肝程度变化和不良反应的发生情况。结果：联合组和对照组的治疗总有效率分别为90.0%和62.5%，两组总有效率比较有显著性差异(P<0.05)。治疗后，联合组患者的血清转氨酶、血脂水平均较对照组显著降低(P<0.05)。治疗中两组均未发现明显不良反应。结论：电针腧穴联合当飞利肝宁对非酒精性脂肪性肝炎有较好的治疗效果，具有很高的临床应用价值。

英文摘要:

ABSTRACT Objective:To investigate the efficacy and safety of electro-acupuncture combined with Dangfei Liganning Capsule in the treatment of Nonalcoholic Fatty Liver Disease (NASH).Methods: Eighty patients who were diagnosed as NASH according to 2010 nonalcoholic fatty liver disease diagnosis and treatment guideline were randomly divided into the combination group (electro-acupuncture combined with Dangfei Liganning Capsule) and control group (Hugan Ning). The patients in both groups were treated by correcting unhealthy lifestyles, dietary control (BMI<24), moderate aerobic exercise on the basis of the corresponding treatment. The control group was given Hugan Ning, 3 times/d, while the combination group was given Dangfei Liganning Capsule with electro-acupuncture acupoints. The changes of ALT, GGT levels, the severity of fatty liver and the adverse reaction were observed and compared.Results: The total effective rate of combination group and control group were respectively 90.0%and 62.5% (P<0.05). The aminotransferase and blood fat of combination group were decreased significantly than those of the control group (P<0.05). No significant adverse reaction was found. Conclusion:Electro-acupuncture combined with Dangfei Liganning Capsule may obtain a favorable effect on nonalcoholic fatty liver disease and was of great clinical value.

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