| 杨秋丽1 王艳云2 刘力山1 刘莉霞3 何秀萍1△.PDCD4 和DNMT1 在卵巢上皮性癌中的表达
及其临床意义[J].现代生物医学进展英文版,2014,14(5):873-877. |
| PDCD4 和DNMT1 在卵巢上皮性癌中的表达
及其临床意义 |
| Expression and Clinical Significance of PDCD4 and DNMT1in Epithelial Ovarian Cancer |
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| DOI： |
| 中文关键词: 卵巢癌 程序性细胞死亡因子4 DNA 甲基转移酶1 表达 |
| 英文关键词: Ovarian Carcinoma Programmed cell death 4 DNA methyltransferase 1 Expression |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：检测PDCD4 和DNMT1 在正常卵巢组织、卵巢良性肿瘤组织、卵巢上皮性癌组织中的表达，并探讨其临床意义。方
法：采用免疫组化法检测20 例正常卵巢、25 例卵巢良性肿瘤、40 例卵巢上皮性癌组织中PDCD4 和DNMT1 的表达情况，分析其
与卵巢上皮性癌临床病理参数之间的关系。结果：正常及良性卵巢组织中PDCD4 的阳性表达率明显高于卵巢癌组(P＜0.05），卵
巢癌的FIGO分期越高，PDCD4 的表达越低，卵巢癌的病理分化程度越低，PDCD4 的表达也越低，PDCD4 的表达与卵巢癌的组
织类型、腹水、年龄、是否绝经无关。正常及良性卵巢组织中DNMT1 的阳性表达率明显低于卵巢癌组(P＜0.05），卵巢癌的病理分
化程度越低，DNMT1 的表达越高，但其与卵巢癌的FIGO分期、组织类型、腹水、年龄、是否绝经均无关。卵巢癌中DNMT1 的与
PDCD4 的表达呈显著负相关(P＜0.05）。结论：PDCD4 和DNMT1在卵巢癌中的表达呈负相关，PDCD4 的表达下调和DNMT1 的
表达上调可能在卵巢癌的发生及发展中起重要作用。 |
| 英文摘要: |
| ABSTRACT Objective:To detect the expression of PDCD4 and DNMT1 in normal ovarian tissues, epithelial benign ovarian tumor
tissues and ovarian epithelial carcinoma tissues, and investigate the clinical significance of PDCD4 and DNMT1 in ovarian epithelial
carcinoma. Methods:The expressions of PDCD4 and DNMT1 in 20 cases of normal ovarian tissues, 25 cases of epithelial benign ovarian
tumor tissues, 40 cases of ovarian epithelial carcinoma tissues were detected by immunohistochemical method. Their relationship with
the clinical pathological parameters of ovarian epithelial carcinoma were analyzed.Results: the positive expression rate of PDCD4 in
normal and benign ovarian tissues were significantly higher than that in the ovarian cancer group (P<0.05).The higher FIGO stage of
ovarian cancer was, the lower PDCD4 expression was; the lower opathological differentiation of varian cancer was ,the lower PDCD4
expression was. The PDCD4 expression was unrelated to the tissue types of ovarian cancer, ascites, age, whether menopause or not. The
positiye expression rate of DNMT1 in normal and benign ovarian tissues were significantly higher than that in the ovarian cancer group
(P<0.05).The lower pathological differentiation of ovarian cancer was, the higher DNMT1 expression was, but it was unrelated to the
tissue types of ovarian cancer, ascites, age, whether menopause or not. The expression of DNMT1 and PDCD4 in ovarian cancer were
significantly negative correlated (P<0.05). Conclusion:The expression of DNMT1 and PDCD4 in Ovarian cancer was negative
correlation.PDCD4 downregulation and DNMT1 upregulation may play an important role in the occurrence and development of ovarian
cancer. |
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